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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes

Fig. 6

Representative results of DNA methylation mapping of UGT1A isoforms. The levels of the DNA methylation of hepatic-type (UGT1A1, UGT1A4, UGT1A6, and UGT1A9) and intestinal-type (UGT1A10 and UGT1A8) genes were examined in adult liver tissues (NLA and NL2), fetal liver tissue (NLF), and adult small intestinal tissue (NSI). In each panel, the open or closed circles located on the horizontal axis indicate the positions of CpG sites arranged in the 5′ to 3′ direction according to the relative distance of each CpG site. The closed circles indicate CpG sites in which tissue-specific expression could be explained by the DNA methylation status

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Clinical Epigenetics

ISSN: 1868-7083

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