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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Whole-genome bisulfite sequencing of cell-free DNA identifies signature associated with metastatic breast cancer

Fig. 2

a Venn diagram showing the overlap of DML lists as generated by WGBS for H, DFS, and MBC sample comparisons. b Three pair-wise comparisons assessing cfDNA differential methylation between H, DFS, and MBC. Pie charts show percentages of differentially hyper- or hypomethylated CpG loci genome-wide and within the displayed genomic contexts. Greater than 90 % of CpG loci are hypomethylated genome-wide in MBC compared with Healthy or DFS. The majority of hypermethylated loci in MBC occur within CpG islands. The number of DML and the percentages are shown within each pie chart

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Clinical Epigenetics

ISSN: 1868-7083

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