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Table 1 Summary of mouse tumor studies

From: Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

Treatment Colon tumor incidence Multiplicity (tumors/mouse) Tumor burden (mm3) Average food consumption (g/day) Mouse weight at end of study (g)
A 25-week study      
 No SFN 23/24 (95.8 %) 5.3 ± 2.8 18.4 ± 15.9 3.5 ± 0.8 45.3 ± 4.9
 Daily SFN 15/21 (71.4 %) 2.8 ± 2.5* 7.1 ± 7.2* 3.9 ± 1.3 43.6 ± 3.8
 Alt SFN 10/11 (90.9 %) 7.2 ± 4.4 22.6 ± 18.3 3.8 ± 1.0 44.0 ± 2.9
B 35-week study      
 −SFN (Nrf2+/+) 28/28 (100 %) 7.0 ± 3.7 62.7 ± 53.5 3.7 ± 0.7 51.3 ± 6.5
 +SFN (Nrf2+/+) 27/28 (96.4 %) 5.7 ± 4.0 26.0 ± 30.2* 3.6 ± 1.5 44.7 ± 7.0
 −SFN (Nrf2−/+) 31/32 (96.8 %) 4.0 ± 2.1 14.6 ± 24.8 3.1 ± 0.6 45.2 ± 8.0
 +SFN (Nrf2−/+) 28/31 (90.3 %) 3.0 ± 2.1 11.7 ± 13.5 3.2 ± 0.5 43.8 ± 6.5
  1. *P < 0.05 vs. corresponding control mice given no dietary SFN