Table 2 Effect of drug treatment on gene expression in YB5 cells
From: Epigenetic synergy between decitabine and platinum derivatives
Methylation | Expression | Quadrant | Analyzed genes | Regulated genes | Change | DAC | Carbo | DAC + Carbo | P value* |
|---|---|---|---|---|---|---|---|---|---|
<10 % | ≥7.08 | Q1 | 5697 | 1514 | Up | 177 | 755 | 527 | <0.0001 |
Down | 58 | 365 | 312 | <0.0001 | |||||
≥10 % | ≥7.08 | Q2 | 1119 | 334 | Up | 64 | 150 | 149 | <0.0001 |
Down | 14 | 81 | 61 | <0.0001 | |||||
<10 % | <7.08 | Q3 | 479 | 22 | Up | 4 | 15 | 7 | 0.0224 |
Down | 0 | 0 | 0 | n/a | |||||
≥10 % | <7.08 | Q4 | 1788 | 73 | Up | 21 | 29 | 44 | 0.0119 |
Down | 1 | 0 | 0 | n/a |