Fig. 4
From: Epigenetic synergy between decitabine and platinum derivatives
Gene expression changes in YB5 cells after drug treatment. Beanplots show changes of expression in 1943 regulated genes compared to baseline after treatment of YB5 cells with decitabine 25 nM (DAC), carboplatin 20 μM (Carbo), and their combination (DAC + Carbo) in the four quadrants defined in Fig. 3. The width of the shape sacks represents histograms of data density. The short lines inside the shapes depict individual data points. Thick horizontal bars show medians. The dotted line behind the shapes shows median of data in all three columns. The expression changes are plotted in log2 units. a–c Carboplatin treatment results in the largest gene expression changes. d Reactivation of methylated silenced genes by combined treatment with decitabine and carboplatin