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Table 4 DIO3 and FOXD2 mRNA expression assessed by quantitative PCR

From: Methylome profiling reveals functions and genes which are differentially methylated in serrated compared to conventional colorectal carcinoma

  

Tumoural cases

All cases

  

SAC

CC

hMSI-H

Non-tumoural

Tumoural

 

n

18

25

8

9

43

 

Median ± SD

0.007 ± 0.095

0.131 ± 0.155

0.0021424 ± 0.008

0.154 ± 0.18

0.054 ± 0.138

DIO3

Mann-Whit. U

 

131

51a/29b

 

110

 

p

 

0.020

0.243a/0.002b

 

0.043

 

Median ± SD

0.01 ± 0.253

0.174 ± 0.331

0.0007 ± 0.003

0.281 ± 0.473

0.095 ± 0.301

FOXD2

Mann-Whit. U

 

142

33a/7b

 

91

 

p

 

0.041

0.031a/<0.001b

 

0.013

  1. SAC Serrated adenocarcinoma, CC Conventional carcinoma, hMSI-H colorectal carcinoma showing typical molecular and histological features of MSI-H
  2. aSAC vs. hMSI-H comparison; bCC vs. hMSI-H comparison