Table 2 Differentially methylated genes between serrated adenocarcinoma and conventional carcinoma obtained from the methylome analysis
Symbol | Gene name and protein function | > meth in: | Fold change | Raw p value | Adj. p value |
|---|---|---|---|---|---|
DIO3 | Type III iodothyronine deiodinase. Inactivation of thyroid hormone | SAC | 209.939.101.331.552 | 7.41E+05 | 0.0001 |
FOXD2 | Forkhead box protein D2. Transcription factor | SAC | 0.889154808110723 | 7.14E+07 | 0.0066 |
OR4N5 | Olfactory receptor, family 4, subfamily N, member 5. G protein-coupled receptor | SAC | 135.181.723.252.813 | 8.99E+08 | 0.0452 |
RIOK3 | RIO kinase 3. Cytoskeleton rearrangement | SAC | 0.635422579240145 | 9.83E+08 | 0.0452 |
WASF3/WAVE3 | Wiskott-Aldrich syndrome protein family, member 3. Cytoskeleton rearrangement | SAC | 120.522.262.330.085 | 1.38E+09 | 0.0467 |
OR51G1 | Olfactory receptor, family 51, subfamily G, member 1. G protein-coupled receptor | SAC | 168.046.340.201.344 | 1.81E+09 | 0.0467 |
BPIFA2/SPLUNC2 | Short palate, lung and nasal epithelium carcinoma associated 2. Lipopolysaccharide binding | SAC | 0.911123350424225 | 2.24E+09 | 0.0467 |
ATP6V1C1 | ATPase, H+ transporting, lysosomal 42 kDa, V1 subunit C1. Intracellular protein sorting and endocytosis | SAC | 160.360.515.634.696 | 2.29E+09 | 0.0467 |
NIPAL4 | NIPA-like domain containing 4. Membrane receptor | SAC | 153.320.826.961.118 | 2.67E+09 | 0.0467 |
LRRK2 | Leucine-rich repeat kinase 2. GTPase and kinase | SAC | 170.637.559.235.708 | 2.72E+09 | 0.0467 |
QPRT | Quinolinate phosphoribosyltransferase. Catabolism of endogenous excitotoxin to neurons | CC | −0.698324044955379 | 3.28E+09 | 0.0467 |
PRR5 | Proline rich 5 (renal). mTOR pathway | SAC | 0.892188635181469 | 3.63E+09 | 0.0467 |
XKR4 | Kell blood group complex subunit-related family, member 4. Apoptosis | SAC | 0.737099384900948 | 3.66E+09 | 0.0467 |
FAM19A5 | Family with sequence similarity 19 (chemokine (C-C motif)-like), A5. Regulation of immune and nervous cells | SAC | 0.734137349204086 | 3.69E+09 | 0.0467 |
POT1 | protection of telomeres 1. Telomere maintenance | SAC | 0.551207360675112 | 3.81E+08 | 0.0467 |