|
Expression
|
DNA methylation
|
---|
|
Obese
|
Control
|
Obese vs control
|
Adjusted P
a
|
Probes
|
Region
|
Obese
|
Control
|
Obese vs control
|
Adjusted P
a
|
---|
|
Av.
|
SD
|
Av.
|
SD
| | | |
Av.
|
SD
|
Av.
|
SD
| |
---|
ABHD5
|
808
|
64
|
1327
|
343
|
0.61
|
9.76E−05
|
cg24595152
|
Body
|
0.57
|
0.06
|
0.4
|
0.1
|
0.17
|
2.04E−04
|
ADCY2
|
24
|
6
|
34
|
8
|
0.71
|
1.08E−02
|
cg07176385
|
Body
|
0.69
|
0.07
|
0.6
|
0.05
|
0.09
|
9.27E−03
|
| | | | | | |
cg27629673
|
Body
|
0.78
|
0.07
|
0.86
|
0.04
|
−0.08
|
8.43E−03
|
| | | | | | |
cg12378867
|
3′UTR
|
0.27
|
0.1
|
0.16
|
0.05
|
0.11
|
4.90E−03
|
ADCY6
|
302
|
36
|
381
|
53
|
0.79
|
3.62E−03
|
cg22689690
|
TSS1500
|
0.04
|
0.02
|
0.02
|
0.01
|
0.02
|
1.61E−03
|
| | | | | | |
cg00160359
|
5′UTR
|
0.78
|
0.06
|
0.7
|
0.04
|
0.08
|
2.89E−03
|
| | | | | | |
cg11661914
|
5′UTR
|
0.26
|
0.09
|
0.14
|
0.05
|
0.12
|
1.33E−03
|
| | | | | | |
cg24092939
|
5′UTR
|
0.18
|
0.1
|
0.07
|
0.03
|
0.11
|
8.58E−04
|
| | | | | | |
cg25196508
|
5′UTR
|
0.28
|
0.13
|
0.11
|
0.07
|
0.17
|
1.12E−03
|
| | | | | | |
cg26266429
|
Body
|
0.19
|
0.07
|
0.1
|
0.07
|
0.09
|
8.53E−04
|
ADCY7
|
108
|
18
|
63
|
19
|
1.72
|
1.76E−04
|
cg23580000
|
1stExon
|
0.86
|
0.07
|
0.93
|
0.03
|
−0.07
|
1.85E−03
|
| | | | | | |
cg16548911
|
Body
|
0.58
|
0.08
|
0.68
|
0.07
|
−0.1
|
6.66E−03
|
ADRB1
|
57
|
16
|
79
|
23
|
0.72
|
2.80E−02
|
cg13848598
|
1stExon
|
0.2
|
0.07
|
0.1
|
0.03
|
0.1
|
7.02E−04
|
| | | | | | |
cg14826456
|
1stExon
|
0.08
|
0.03
|
0.05
|
0.02
|
0.03
|
1.45E−03
|
CIDEA
|
164
|
44
|
567
|
187
|
0.29
|
1.01E−06
|
cg14976646
|
TSS1500
|
0.08
|
0.03
|
0.05
|
0.01
|
0.03
|
1.34E−03
|
| | | | | | |
cg19883905
|
TSS1500
|
0.05
|
0.02
|
0.03
|
0.01
|
0.02
|
4.68E−03
|
| | | | | | |
cg14923652
|
3′UTR
|
0.93
|
0.03
|
0.85
|
0.04
|
0.08
|
4.32E−05
|
CIDEC
|
1857
|
174
|
2597
|
265
|
0.71
|
2.42E−05
|
cg03604278
|
TSS1500
|
0.3
|
0.09
|
0.14
|
0.02
|
0.16
|
1.20E−05
|
| | | | | | |
cg07222243
|
5′UTR
|
0.28
|
0.07
|
0.13
|
0.05
|
0.15
|
3.13E−05
|
EDNRA
|
327
|
78
|
463
|
116
|
0.71
|
9.64E−03
|
cg17073859
|
TSS1500
|
0.48
|
0.05
|
0.37
|
0.04
|
0.11
|
1.27E−04
|
| | | | | | |
cg00379467
|
TSS200
|
0.23
|
0.07
|
0.12
|
0.04
|
0.11
|
5.01E−04
|
| | | | | | |
cg00974629
|
TSS200
|
0.38
|
0.07
|
0.25
|
0.04
|
0.13
|
7.57E−05
|
| | | | | | |
cg05618426
|
TSS200
|
0.26
|
0.09
|
0.13
|
0.02
|
0.13
|
9.82E−05
|
EDNRB
|
618
|
61
|
488
|
81
|
1.27
|
3.57E−03
|
cg07974719
|
TSS1500
|
0.31
|
0.06
|
0.24
|
0.03
|
0.07
|
9.57E−03
|
| | | | | | |
cg12983394
|
TSS1500
|
0.05
|
0.04
|
0.02
|
0.01
|
0.03
|
5.52E−03
|
| | | | | | |
cg12120741
|
1stExon
|
0.29
|
0.06
|
0.19
|
0.04
|
0.1
|
3.77E−04
|
| | | | | | |
cg18210860
|
Body
|
0.24
|
0.12
|
0.1
|
0.03
|
0.14
|
3.35E−04
|
GNG7
|
78
|
14
|
112
|
21
|
0.69
|
9.31E−04
|
cg01286319
|
5′UTR
|
0.53
|
0.1
|
0.67
|
0.07
|
−0.14
|
1.64E−03
|
| | | | | | |
cg02309655
|
5′UTR
|
0.3
|
0.08
|
0.19
|
0.04
|
0.11
|
6.22E−03
|
| | | | | | |
cg06371583
|
5′UTR
|
0.26
|
0.06
|
0.19
|
0.04
|
0.07
|
8.78E−03
|
| | | | | | |
cg08461840
|
5′UTR
|
0.54
|
0.11
|
0.71
|
0.09
|
−0.17
|
7.26E−04
|
| | | | | | |
cg11906607
|
5′UTR
|
0.33
|
0.1
|
0.21
|
0.07
|
0.12
|
3.69E−03
|
| | | | | | |
cg13078421
|
5′UTR
|
0.09
|
0.05
|
0.04
|
0.01
|
0.05
|
3.72E−04
|
| | | | | | |
cg18229071
|
5′UTR
|
0.54
|
0.07
|
0.64
|
0.05
|
−0.1
|
1.81E−03
|
| | | | | | |
cg18754118
|
5′UTR
|
0.34
|
0.07
|
0.25
|
0.03
|
0.09
|
2.71E−03
|
| | | | | | |
cg19382697
|
5′UTR
|
0.77
|
0.05
|
0.84
|
0.03
|
−0.07
|
1.03E−03
|
| | | | | | |
cg19853565
|
5′UTR
|
0.15
|
0.13
|
0.05
|
0.02
|
0.1
|
1.74E−03
|
| | | | | | |
cg20091384
|
5′UTR
|
0.24
|
0.07
|
0.16
|
0.03
|
0.08
|
5.42E−03
|
| | | | | | |
cg22023664
|
5′UTR
|
0.76
|
0.09
|
0.88
|
0.02
|
−0.12
|
2.35E−04
|
| | | | | | |
cg24874003
|
5′UTR
|
0.2
|
0.12
|
0.07
|
0.03
|
0.13
|
7.32E−04
|
| | | | | | |
cg27176392
|
5′UTR
|
0.92
|
0.02
|
0.87
|
0.03
|
0.05
|
1.28E−03
|
IL6R
|
141
|
16
|
103
|
13
|
1.36
|
1.47E−04
|
cg24346686
|
TSS1500
|
0.13
|
0.04
|
0.09
|
0.03
|
0.04
|
7.89E−03
|
| | | | | | |
cg04437762
|
Body
|
0.67
|
0.07
|
0.82
|
0.05
|
−0.15
|
1.94E−05
|
| | | | | | |
cg17001401
|
Body
|
0.31
|
0.08
|
0.15
|
0.05
|
0.16
|
4.73E−05
|
| | | | | | |
cg25135018
|
Body
|
0.76
|
0.09
|
0.88
|
0.05
|
−0.12
|
5.63E−04
|
INSR
|
192
|
19
|
244
|
42
|
0.79
|
6.85E−03
|
cg00428638
|
Body
|
0.29
|
0.09
|
0.16
|
0.08
|
0.13
|
3.34E−03
|
| | | | | | |
cg09779027
|
Body
|
0.33
|
0.09
|
0.16
|
0.05
|
0.17
|
3.99E−05
|
| | | | | | |
cg10148591
|
Body
|
0.25
|
0.08
|
0.13
|
0.03
|
0.12
|
2.11E−04
|
| | | | | | |
cg23845936
|
Body
|
0.63
|
0.08
|
0.43
|
0.08
|
0.2
|
4.44E−05
|
NPR1
|
265
|
41
|
374
|
44
|
0.71
|
2.21E−04
|
cg07106989
|
Body
|
0.9
|
0.02
|
0.81
|
0.04
|
0.09
|
4.62E−05
|
PDE3B
|
701
|
119
|
972
|
169
|
0.72
|
2.00E−03
|
cg03439703
|
TSS1500
|
0.17
|
0.04
|
0.11
|
0.02
|
0.06
|
3.83E−04
|
| | | | | | |
cg18222865
|
TSS1500
|
0.34
|
0.06
|
0.2
|
0.05
|
0.14
|
1.10E−04
|
| | | | | | |
cg21901307
|
TSS1500
|
0.1
|
0.03
|
0.06
|
0.01
|
0.04
|
1.12E−03
|
| | | | | | |
cg12177909
|
Body
|
0.31
|
0.1
|
0.19
|
0.05
|
0.12
|
2.74E−03
|
PDE5A
|
118
|
14
|
90
|
17
|
1.31
|
3.31E−03
|
cg15191465
|
TSS1500
|
0.05
|
0.01
|
0.03
|
0.01
|
0.02
|
2.68E−03
|
| | | | | | |
cg19191984
|
TSS1500
|
0.08
|
0.02
|
0.05
|
0.01
|
0.03
|
3.78E−03
|
| | | | | | |
cg06531595
|
Body
|
0.78
|
0.05
|
0.71
|
0.03
|
0.07
|
2.47E−03
|
PLIN2
|
506
|
102
|
408
|
53
|
1.24
|
3.62E−02
|
cg03885527
|
Body
|
0.84
|
0.04
|
0.9
|
0.03
|
−0.06
|
4.18E−03
|
PPARG
|
1607
|
142
|
2096
|
258
|
0.77
|
4.08E−04
|
cg01412654
|
TSS1500
|
0.47
|
0.08
|
0.33
|
0.06
|
0.14
|
1.87E−04
|
| | | | | | |
cg18063278
|
TSS1500
|
0.28
|
0.09
|
0.15
|
0.05
|
0.13
|
7.36E−04
|
| | | | | | |
cg25929976
|
TSS1500
|
0.24
|
0.07
|
0.13
|
0.04
|
0.11
|
1.21E−04
|
| | | | | | |
cg16197186
|
5′UTR
|
0.91
|
0.03
|
0.84
|
0.05
|
0.07
|
2.62E−04
|
| | | | | | |
cg16827534
|
5′UTR
|
0.31
|
0.13
|
0.15
|
0.05
|
0.16
|
7.11E−04
|
| | | | | | |
cg10499651
|
Body
|
0.23
|
0.11
|
0.09
|
0.02
|
0.14
|
8.70E−05
|
PRKAR2B
|
1956
|
324
|
2467
|
178
|
0.79
|
3.69E−03
|
cg03661844
|
Body
|
0.95
|
0.03
|
0.79
|
0.11
|
0.16
|
5.45E−06
|
| | | | | | |
cg10691109
|
Body
|
0.1
|
0.06
|
0.04
|
0.01
|
0.06
|
9.79E−05
|
| | | | | | |
cg26104690
|
Body
|
0.77
|
0.08
|
0.66
|
0.07
|
0.11
|
3.64E−03
|
-
Av average
-
a Adjusted P comparing groups in Limma (in DNA methylation analysis adjusting for age)