Expression | DNA methylation | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Obese | Control | Obese vs control | Adjusted P a | Probes | Region | Obese | Control | Obese vs control | Adjusted P a | |||||
Av. | SD | Av. | SD | Av. | SD | Av. | SD | |||||||
ABHD5 | 808 | 64 | 1327 | 343 | 0.61 | 9.76E−05 | cg24595152 | Body | 0.57 | 0.06 | 0.4 | 0.1 | 0.17 | 2.04E−04 |
ADCY2 | 24 | 6 | 34 | 8 | 0.71 | 1.08E−02 | cg07176385 | Body | 0.69 | 0.07 | 0.6 | 0.05 | 0.09 | 9.27E−03 |
cg27629673 | Body | 0.78 | 0.07 | 0.86 | 0.04 | −0.08 | 8.43E−03 | |||||||
cg12378867 | 3′UTR | 0.27 | 0.1 | 0.16 | 0.05 | 0.11 | 4.90E−03 | |||||||
ADCY6 | 302 | 36 | 381 | 53 | 0.79 | 3.62E−03 | cg22689690 | TSS1500 | 0.04 | 0.02 | 0.02 | 0.01 | 0.02 | 1.61E−03 |
cg00160359 | 5′UTR | 0.78 | 0.06 | 0.7 | 0.04 | 0.08 | 2.89E−03 | |||||||
cg11661914 | 5′UTR | 0.26 | 0.09 | 0.14 | 0.05 | 0.12 | 1.33E−03 | |||||||
cg24092939 | 5′UTR | 0.18 | 0.1 | 0.07 | 0.03 | 0.11 | 8.58E−04 | |||||||
cg25196508 | 5′UTR | 0.28 | 0.13 | 0.11 | 0.07 | 0.17 | 1.12E−03 | |||||||
cg26266429 | Body | 0.19 | 0.07 | 0.1 | 0.07 | 0.09 | 8.53E−04 | |||||||
ADCY7 | 108 | 18 | 63 | 19 | 1.72 | 1.76E−04 | cg23580000 | 1stExon | 0.86 | 0.07 | 0.93 | 0.03 | −0.07 | 1.85E−03 |
cg16548911 | Body | 0.58 | 0.08 | 0.68 | 0.07 | −0.1 | 6.66E−03 | |||||||
ADRB1 | 57 | 16 | 79 | 23 | 0.72 | 2.80E−02 | cg13848598 | 1stExon | 0.2 | 0.07 | 0.1 | 0.03 | 0.1 | 7.02E−04 |
cg14826456 | 1stExon | 0.08 | 0.03 | 0.05 | 0.02 | 0.03 | 1.45E−03 | |||||||
CIDEA | 164 | 44 | 567 | 187 | 0.29 | 1.01E−06 | cg14976646 | TSS1500 | 0.08 | 0.03 | 0.05 | 0.01 | 0.03 | 1.34E−03 |
cg19883905 | TSS1500 | 0.05 | 0.02 | 0.03 | 0.01 | 0.02 | 4.68E−03 | |||||||
cg14923652 | 3′UTR | 0.93 | 0.03 | 0.85 | 0.04 | 0.08 | 4.32E−05 | |||||||
CIDEC | 1857 | 174 | 2597 | 265 | 0.71 | 2.42E−05 | cg03604278 | TSS1500 | 0.3 | 0.09 | 0.14 | 0.02 | 0.16 | 1.20E−05 |
cg07222243 | 5′UTR | 0.28 | 0.07 | 0.13 | 0.05 | 0.15 | 3.13E−05 | |||||||
EDNRA | 327 | 78 | 463 | 116 | 0.71 | 9.64E−03 | cg17073859 | TSS1500 | 0.48 | 0.05 | 0.37 | 0.04 | 0.11 | 1.27E−04 |
cg00379467 | TSS200 | 0.23 | 0.07 | 0.12 | 0.04 | 0.11 | 5.01E−04 | |||||||
cg00974629 | TSS200 | 0.38 | 0.07 | 0.25 | 0.04 | 0.13 | 7.57E−05 | |||||||
cg05618426 | TSS200 | 0.26 | 0.09 | 0.13 | 0.02 | 0.13 | 9.82E−05 | |||||||
EDNRB | 618 | 61 | 488 | 81 | 1.27 | 3.57E−03 | cg07974719 | TSS1500 | 0.31 | 0.06 | 0.24 | 0.03 | 0.07 | 9.57E−03 |
cg12983394 | TSS1500 | 0.05 | 0.04 | 0.02 | 0.01 | 0.03 | 5.52E−03 | |||||||
cg12120741 | 1stExon | 0.29 | 0.06 | 0.19 | 0.04 | 0.1 | 3.77E−04 | |||||||
cg18210860 | Body | 0.24 | 0.12 | 0.1 | 0.03 | 0.14 | 3.35E−04 | |||||||
GNG7 | 78 | 14 | 112 | 21 | 0.69 | 9.31E−04 | cg01286319 | 5′UTR | 0.53 | 0.1 | 0.67 | 0.07 | −0.14 | 1.64E−03 |
cg02309655 | 5′UTR | 0.3 | 0.08 | 0.19 | 0.04 | 0.11 | 6.22E−03 | |||||||
cg06371583 | 5′UTR | 0.26 | 0.06 | 0.19 | 0.04 | 0.07 | 8.78E−03 | |||||||
cg08461840 | 5′UTR | 0.54 | 0.11 | 0.71 | 0.09 | −0.17 | 7.26E−04 | |||||||
cg11906607 | 5′UTR | 0.33 | 0.1 | 0.21 | 0.07 | 0.12 | 3.69E−03 | |||||||
cg13078421 | 5′UTR | 0.09 | 0.05 | 0.04 | 0.01 | 0.05 | 3.72E−04 | |||||||
cg18229071 | 5′UTR | 0.54 | 0.07 | 0.64 | 0.05 | −0.1 | 1.81E−03 | |||||||
cg18754118 | 5′UTR | 0.34 | 0.07 | 0.25 | 0.03 | 0.09 | 2.71E−03 | |||||||
cg19382697 | 5′UTR | 0.77 | 0.05 | 0.84 | 0.03 | −0.07 | 1.03E−03 | |||||||
cg19853565 | 5′UTR | 0.15 | 0.13 | 0.05 | 0.02 | 0.1 | 1.74E−03 | |||||||
cg20091384 | 5′UTR | 0.24 | 0.07 | 0.16 | 0.03 | 0.08 | 5.42E−03 | |||||||
cg22023664 | 5′UTR | 0.76 | 0.09 | 0.88 | 0.02 | −0.12 | 2.35E−04 | |||||||
cg24874003 | 5′UTR | 0.2 | 0.12 | 0.07 | 0.03 | 0.13 | 7.32E−04 | |||||||
cg27176392 | 5′UTR | 0.92 | 0.02 | 0.87 | 0.03 | 0.05 | 1.28E−03 | |||||||
IL6R | 141 | 16 | 103 | 13 | 1.36 | 1.47E−04 | cg24346686 | TSS1500 | 0.13 | 0.04 | 0.09 | 0.03 | 0.04 | 7.89E−03 |
cg04437762 | Body | 0.67 | 0.07 | 0.82 | 0.05 | −0.15 | 1.94E−05 | |||||||
cg17001401 | Body | 0.31 | 0.08 | 0.15 | 0.05 | 0.16 | 4.73E−05 | |||||||
cg25135018 | Body | 0.76 | 0.09 | 0.88 | 0.05 | −0.12 | 5.63E−04 | |||||||
INSR | 192 | 19 | 244 | 42 | 0.79 | 6.85E−03 | cg00428638 | Body | 0.29 | 0.09 | 0.16 | 0.08 | 0.13 | 3.34E−03 |
cg09779027 | Body | 0.33 | 0.09 | 0.16 | 0.05 | 0.17 | 3.99E−05 | |||||||
cg10148591 | Body | 0.25 | 0.08 | 0.13 | 0.03 | 0.12 | 2.11E−04 | |||||||
cg23845936 | Body | 0.63 | 0.08 | 0.43 | 0.08 | 0.2 | 4.44E−05 | |||||||
NPR1 | 265 | 41 | 374 | 44 | 0.71 | 2.21E−04 | cg07106989 | Body | 0.9 | 0.02 | 0.81 | 0.04 | 0.09 | 4.62E−05 |
PDE3B | 701 | 119 | 972 | 169 | 0.72 | 2.00E−03 | cg03439703 | TSS1500 | 0.17 | 0.04 | 0.11 | 0.02 | 0.06 | 3.83E−04 |
cg18222865 | TSS1500 | 0.34 | 0.06 | 0.2 | 0.05 | 0.14 | 1.10E−04 | |||||||
cg21901307 | TSS1500 | 0.1 | 0.03 | 0.06 | 0.01 | 0.04 | 1.12E−03 | |||||||
cg12177909 | Body | 0.31 | 0.1 | 0.19 | 0.05 | 0.12 | 2.74E−03 | |||||||
PDE5A | 118 | 14 | 90 | 17 | 1.31 | 3.31E−03 | cg15191465 | TSS1500 | 0.05 | 0.01 | 0.03 | 0.01 | 0.02 | 2.68E−03 |
cg19191984 | TSS1500 | 0.08 | 0.02 | 0.05 | 0.01 | 0.03 | 3.78E−03 | |||||||
cg06531595 | Body | 0.78 | 0.05 | 0.71 | 0.03 | 0.07 | 2.47E−03 | |||||||
PLIN2 | 506 | 102 | 408 | 53 | 1.24 | 3.62E−02 | cg03885527 | Body | 0.84 | 0.04 | 0.9 | 0.03 | −0.06 | 4.18E−03 |
PPARG | 1607 | 142 | 2096 | 258 | 0.77 | 4.08E−04 | cg01412654 | TSS1500 | 0.47 | 0.08 | 0.33 | 0.06 | 0.14 | 1.87E−04 |
cg18063278 | TSS1500 | 0.28 | 0.09 | 0.15 | 0.05 | 0.13 | 7.36E−04 | |||||||
cg25929976 | TSS1500 | 0.24 | 0.07 | 0.13 | 0.04 | 0.11 | 1.21E−04 | |||||||
cg16197186 | 5′UTR | 0.91 | 0.03 | 0.84 | 0.05 | 0.07 | 2.62E−04 | |||||||
cg16827534 | 5′UTR | 0.31 | 0.13 | 0.15 | 0.05 | 0.16 | 7.11E−04 | |||||||
cg10499651 | Body | 0.23 | 0.11 | 0.09 | 0.02 | 0.14 | 8.70E−05 | |||||||
PRKAR2B | 1956 | 324 | 2467 | 178 | 0.79 | 3.69E−03 | cg03661844 | Body | 0.95 | 0.03 | 0.79 | 0.11 | 0.16 | 5.45E−06 |
cg10691109 | Body | 0.1 | 0.06 | 0.04 | 0.01 | 0.06 | 9.79E−05 | |||||||
cg26104690 | Body | 0.77 | 0.08 | 0.66 | 0.07 | 0.11 | 3.64E−03 |