Table 4 Pathological characteristics of IDC cases, according to menopausal status
From: Breast cancer risk and imprinting methylation in blood
Characteristic | All cases (n = 189) | Pre-menopausal (n = 66) | Post-menopausal (n = 123) |
|---|---|---|---|
Grade | |||
 Grade 1 | 23 (12.2 %) | 6 (9 %) | 17 (13.8 %) |
 Grade 2 | 84 (44.4 %) | 30 (45.5 %) | 54 (43.9 %) |
 Grade 3 | 81 (42.9 %) | 30 (45.5 %) | 51 (41.5 %) |
 Missing info. | 1 (0.5 %) | – | 1 (0.8 %) |
Lymph node involvement | |||
 None | 119 (63 %) | 38 (57.6 %) | 81 (65.9 %) |
 Axillary lymph nodes | 69 (36.5 %) | 28 (42.4 %) | 41 (33.3 %) |
 Missing info. | 1 (0.5 %) | – | 1 (0.8 %) |
Hormone receptor status | |||
 ER positive | 146 (77.2 %) | 54 (81.8 %) | 92 (74.8 %) |
 ER negative | 43 (22.8 %) | 12 (18.2 %) | 31 (25.2 %) |
 PR positive | 145 (76.7 %) | 53 (80.3 %) | 92 (74.8 %) |
 PR negative | 44 (23.3 %) | 13 (19.7 %) | 31 (25.2 %) |
HER2 receptor status | |||
 Positive | 22 (11.6 %) | 11 (16.7 %) | 11 (9 %) |
 Negative | 164 (86.8 %) | 54 (81.8 %) | 110 (89.4 %) |
 Missing info. | 3 (1.6 %) | 1 (1.5 %) | 2 (1.6 %) |
Nottingham prognostic index (NPI) | |||
 Good (NPI ≤ 3.4) | 71 (37.6 %) | 20 (30.3 %) | 51 (41.5 %) |
 Moderate (NPI 3.41–5.4) | 74 (39.1 %) | 32 (48.5 %) | 42 (34.2 %) |
 Poor (NPI > 5.41) | 35 (18.5 %) | 9 (13.6 %) | 26 (21.1 %) |
 Missing info. | 9 (4.8 %) | 5 (7.6 %) | 4 (3.2 %) |