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Table 1 Average methylation levels for imprinted gene DMRs

From: Breast cancer risk and imprinting methylation in blood

Cohort

Imprinted gene DMRs

Chr. 6

Chr. 11

Chr. 13

Chr. 15

Chr. 19

PLAGL1

H19

IGF2

KvDMR

RB1

SNRPN

PEG3

Combined

55.78 (4.92)

59.76 (4.19)

48.50 (5.72)

44.28 (2.36)

68.61 (4.65)

43.97 (3.00)

52.30 (2.99)

Disease-free

55.91 (4.92)

59.59 (4.35)

48.15 (5.77)

44.17 (2.34)

68.61 (4.30)

44.03 (3.03)

52.05 (2.93)

DCIS

53.90 (3.60)

59.70 (3.79)

49.52 (5.66)

45.81 (1.99)

68.22 (3.95)

43.62 (3.20)

53.29 (3.61)

IDC

55.92 (5.08)

60.10 (3.97)

48.94 (5.61)

44.13 (2.36)

68.68 (5.38)

43.93 (2.91)

52.57 (2.89)

  1. Average percent methylation (%) reported (and standard deviation). Combined cohort included all disease-free women and breast cancer cases n = 593. Disease-free women n = 363. DCIS (ductal carcinoma in situ) n = 41. IDC (invasive ductal carcinoma) n = 189
  2. PLAGL1 pleomorphic adenoma gene like 1, H19 H19, imprinted maternally expressed non-coding transcript-imprint control region 1, IGF2 insulin-like growth factor 2. KvDMR 11p15 region imprint control region 2, RB1 retinoblastoma 1. SNRPN small nuclear ribonucleoprotein polypeptide N, PEG3 paternally expressed gene 3. DMR: differentially methylated region. Chr: chromosome