Table 3 Performance of methylation biomarkers to detect CIN3+ in hrHPV-positive women at training and testing sets
From: Triage of high-risk human papillomavirus-positive women by methylated POU4F3
| Â | Â | Gene name | ||||
|---|---|---|---|---|---|---|
| Â | POU4F3 | HS3ST2 | AJAP1 | SOX1 | PAX1 | |
| Â | M-index cutoff value | 38 | 2 | 2 | 4 | 4 |
Training set (N = 68) | Sensitivity (%) | 79 | 67 | 63 | 78 | 70 |
Specificity (%) | 78 | 89 | 64 | 71 | 89 | |
PPV (%) | 83 | 90 | 71 | 80 | 90 | |
NPV (%) | 72 | 65 | 55 | 69 | 68 | |
Testing set (N = 55) | Sensitivity (%) | 74 | 55 | 80 | 63 | 60 |
Specificity (%) | 89 | 100 | 74 | 74 | 100 | |
PPV (%) | 93 | 100 | 85 | 82 | 100 | |
NPV (%) | 64 | 56 | 67 | 52 | 58 | |