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Table 2 Cell growth IC50 of HKMT inhibitors in MDA-MB-231 cells

From: Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells

Cell growth assay (IC50 μM)

HKMT-1-005

BIX-01294

UNC0638

GSK343

Cell viability (MTT)

4.3

9.6

8.2

>15

Clonogenic

0.41

1.4

1.1

>50

  1. IC50s (μM) for the dual inhibitor compounds HKMT-1-005 and HKMT-1-011 in cell viability (MTT assay) or clonogenic growth assays of MDA-MB-231 cells compared to the starting point for the chemical library BIX-01294, as well as UNC0638 and GSK343