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Table 2 Cell growth IC50 of HKMT inhibitors in MDA-MB-231 cells

From: Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells

Cell growth assay (IC50 μM) HKMT-1-005 BIX-01294 UNC0638 GSK343
Cell viability (MTT) 4.3 9.6 8.2 >15
Clonogenic 0.41 1.4 1.1 >50
  1. IC50s (μM) for the dual inhibitor compounds HKMT-1-005 and HKMT-1-011 in cell viability (MTT assay) or clonogenic growth assays of MDA-MB-231 cells compared to the starting point for the chemical library BIX-01294, as well as UNC0638 and GSK343