| IGF2DMR methylation | H19 methylation | |||||
---|---|---|---|---|---|---|---|
 | bètaa | 95 % CI | P value | bètaa | 95 % CI | P value | |
Model 1: adjusted for correlations between CpG sites, bisulphite batch, gestational age at birth | |||||||
Maternal tobacco smoking | Â | Â | Â | Â | Â | Â | |
No (n = 334) | Reference | Reference | |||||
First trimester only (n = 47) | −0.68 | −1.67; 0.31 | 0.178 | 0.61 | −0.13; 1.35 | 0.108 | |
Continued smoking, all (n = 125) | −1.14 | −1.81; −0.47 | 0.001 | −0.24 | −0.75; 0.26 | 0.348 | |
 | <5 cigarettes per day (n = 41) | −1.06 | −2.13; −0.00 | 0.050 | −0.90 | −1.70; −0.11 | 0.026 |
 | ≥5 cigarettes per day (n = 56) | −1.12 | −2.06; −0.18 | 0.019 | −0.13 | −0.82; 0.56 | 0.703 |
P for trend | 0.006 | 0.298 | |||||
Paternal tobacco smoking | Â | Â | Â | Â | Â | Â | |
No (n = 207) | Reference | Reference | |||||
Yes (n = 125) | −0.24 | −0.96; 0.48 | 0.519 | −0.10 | −0.61; 0.41 | 0.707 | |
 | <5 cigarettes per day (n = 57) | −0.26 | −1.22; 0.70 | 0.597 | −0.19 | −0.87; 0.50 | 0.592 |
 | ≥5 cigarettes per day (n = 67) | −0.16 | −1.06; 0.73 | 0.719 | −0.04 | −0.68; 0.60 | 0.893 |
P for trend | 0.643 | 0.795 | |||||
Model 2: model 1 + maternal characteristics (age, educational level, parity, BMI, periconception folic acid supplement use) and fetal gender | |||||||
Maternal tobacco smoking | Â | Â | Â | Â | Â | Â | |
No (n = 334) | Reference | Reference | |||||
First trimester only (n = 47) | −0.70 | −1.71; 0.31 | 0.175 | 0.56 | −0.20; 1.32 | 0.146 | |
Continued smoking, all (n = 125) | −1.03 | −1.76; −0.30 | 0.006 | −0.37 | −0.94; 0.20 | 0.195 | |
 | <5 cigarettes per day (n = 41) | −1.01 | −1.89; 0.10 | 0.069 | −0.96 | −1.78; −0.14 | 0.021 |
 | ≥5 cigarettes per day (n = 56) | −0.89 | −2.10; 0.08 | 0.079 | −0.20 | −0.93; 0.54 | 0.602 |
P for trend | 0.030 | 0.242 | |||||
Paternal tobacco smoking | Â | Â | Â | Â | Â | Â | |
No (n = 207) | Reference | Reference | |||||
Yes (n = 125) | −0.17 | −0.91; 0.58 | 0.663 | −0.23 | −0.75; 0.30 | 0.393 | |
 | <5 cigarettes per day (n = 57) | −0.20 | −1.18; 0.77 | 0.681 | −0.23 | −0.92; 0.45 | 0.502 |
 | ≥5 cigarettes per day (n = 67) | −0.07 | −1.01; 0.88 | 0.887 | −0.25 | −0.91; 0.42 | 0.463 |
P for trend | 0.809 | 0.395 |