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Table 1 Summary of reports indicating that tobacco smoking evokes hypomethylation at single CpG sites in white blood cells

From: A varying T cell subtype explains apparent tobacco smoking induced single CpG hypomethylation in whole blood

Report Hypomethylationa Methylation change
  Maxb cg19859270c cg03636183c
% of CpG sites (n) (%)
Whole blood
 Breitling et al., 2011 [1] 84 (13) −14 −4.3 −12.6
 Wan et al., 2012 [6] 60 (15) −8 −2; −2 −8; −6
 Zeilinger et al., 2013 [7] 62 (29) −25 −1.4; −2 −15; −17
 Shenker et.al., 2013 [3] 83 (36) −16 n/a −7; −8
 Sun et al., 2013 [4] 93 (15) −10 −2.1; −2.2 −9.6; −3
 Tsaprouni et al., 2014 [5] 96 (30) −28 −3.5; −2.7 −13.4; −10.6
PBMC
 Dogan et al., 2014 [2] 60 (30) −19 −10 n/a
  1. n/a not available
  2. aDescribes the methylation change in smokers vs. non-smokers of the prominent highlighted single CpGs
  3. bIndicates the maximum of methylation change at single CpG
  4. cHighlighted are values for the main and replicated cohorts of appropriate studies