Fig. 4

Overlaps in affected loci between Turner and Klinefelter samples. a Venn diagram showing the intersections between four comparisons. The comparisons are abbreviated as T-M, T-F, K-M, and K-F, where M male, F female, T Turner, K Klinefelter. Different intersection groups are labeled from G1 to G15. Below each group name the total number of genes is given as well as the number of genes on the X chromosome (in parenthesis). b Relative direction of methylation changes between the four different comparisons. The X-linked (upper right) and autosomal (lower left) loci are shown separately. The numbers in the Table correspond to the common genes between the X- and the Y-axis categories. The red two-headed arrows point to the gene numbers that switched orientation in their methylation changes. Blue dashed boxes highlight the X-linked genes that are hypomethylated in Klinefelter samples in comparison to female samples, suggesting weaker X inactivation in Klinefelter than in female samples