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Table 2 Summary table with P values for the comparisons of tumors and normal mucosae from patients and healthy donors from the Colonomics study

From: Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer

 

Gene expression

DNA methylation

 

N vs. A

A vs. T

ANOVA

N vs. A

A vs. T

ANOVA

AKR1B1

0.9482

0.0171

0.007

0.7758

<0.0001

<0.0001

HPGD

<0.0001

<0.0001

<0.0001

–

–

0.076

PTGDR

0.2583

<0.0001

<0.0001

–

–

0.1083

PTGDS

<0.0001

<0.0001

<0.0001

–

–

0.0837

PTGER1

0.7856

0.0341

0.0414

0.8720

0.0052

<0.0001

PTGER2

<0.0001

<0.0001

<0.0001

–

–

0.3878

PTGER3

<0.0001

0.0037

<0.0001

0.8859

<0.0001

<0.0001

PTGER4

0.0005

<0.0001

<0.0001

–

–

0.9691

PTGES

<0.0001

<0.0001

<0.0001

0.6580

0.0222

0.0147

PTGES2

0.0158

<0.0001

<0.0001

–

–

0.6959

PTGES3

<0.0001

<0.0001

<0.0001

–

–

0.0545

PTGFR

<0.0001

<0.0001

<0.0001

0.7811

<0.0001

<0.0001

PTGIR

0.0005

0.0086

0.0003

0.9245

<0.0001

<0.0001

PTGIS

<0.0001

<0.0001

<0.0001

0.9392

<0.0001

<0.0001

PTGS1

<0.0001

<0.0001

<0.0001

0.0118

<0.0001

<0.0001

PTGS2

<0.0001

0.0091

<0.0001

0.9866

<0.0001

<0.0001

TBXA2R

<0.0001

<0.0001

<0.0001

0.0362

0.0029

<0.0001

  1. ANOVA test was applied to determine significant differences among the three types of sample. Genes with significant differences (P < 0.05) were further evaluated with Tukey’s range test for differences of normal colonic mucosae from healthy donors (N) versus adjacent tissue from CRC patients (A), and of adjacent mucosae (A) versus CRC tumors (T)
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Clinical Epigenetics

ISSN: 1868-7083

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