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Table 3 Multivariate analysis of overall survival and disease-free survival among male patients (N = 301)

From: Different prognostic effect of CpG island methylation according to sex in colorectal cancer patients treated with adjuvant FOLFOX

  

Overall survival

Disease-free survival

  

Adjusted HR (95 % CI)

p value

Adjusted HR (95 % CI)

p value

Concurrent methylation

Present

5.23 (2.45–11.17)

<0.001

3.66 (1.82–7.36)

<0.001

Not present

1

 

1

 

Angiolymphatic invasion

Present

4.41 (1.97–9.85)

<0.001

2.33 (1.30–4.18)

0.005

Not present

1

 

1

 

Age (continuous variable)

 

1.032 (0.99–1.07)

0.11

  

Histology

MAC

3.47 (0.97–12.41)

0.056

  

Non-MAC

1

   

Perineural invasion

Present

  

2.20 (1.26–3.85)

0.006

Not present

  

1

 
  1. CI confidence interval, MAC mucinous adenocarcinoma
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Clinical Epigenetics

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