Fig. 7
Effect of DNA methylation on gene regulation. Gene features associated with newly methylated regions that also had differential gene expression >3 SD from the mean were sorted by methylation in 3′UTR, 5′UTR, coding sequences (CDS), intergenic regions, introns, and promoters. These were then correlated with log2-fold-change (differential gene expression) between infected and uninfected samples for their respective genes. DNA methylation peaks were considered intergenic when located 3 kb or more from a TSS or TTS and effects on transcription were determined for the nearest gene. Transcriptional changes of genes with DNA methylation were compared to those without. *p < 0.05, **p < 0.01. Data are derived from the average of three donors