Fig. 5
A. phagocytophilum infection causes an increase in exon DNA methylation. Identification of gene features with DNA methylation enrichment unique to A. phagocytophilum-infected neutrophils and uninfected neutrophils was performed using CEAS. Only the most significant peaks, those with a −10*log10 (p value) > 100, were analyzed. Features investigated include a 5′ and 3′ UTRs and b exons, introns, and the sum of all gene features. White bars denote the percentage of the genome annotated to that particular feature (genomic background), gray bars denote the average percentage of regions of DNA methylation unique to A. phagocytophilum-infected human peripheral blood neutrophils (PMN.Aph), and black bars denote the average percentage of regions of methylation unique to uninfected cells (PMN); error bars show sem for each group. Tables in c shows the exact percentage of DNA methylation enrichment for each particular feature and sem for each group. Data shown represent the average of three donors