| |
First PC
|
Second PC
|
Third PC
|
|---|
|
% of variance explained
|
0.064
|
0.034
|
0.022
|
|
Minimum p value chips
|
0.327
|
0.124
|
0.516
|
|
Covariates
| | | |
|
Case/control status
|
0.02
|
0.0005
|
0.23
|
|
Age
|
0.00012
|
0.63
|
0.16
|
|
Weight
|
0.84
|
0.10
|
0.01
|
|
Height
|
0.73
|
0.59
|
0.60
|
|
BMI (continuous)
|
0.74
|
0.14
|
0.01
|
|
BMI (categorical)
| | | |
|
Underweight
|
0.50
|
0.11
|
0.44
|
|
Overweight
|
0.86
|
0.11
|
0.34
|
|
Obese
|
0.96
|
0.20
|
0.01
|
|
Physical activity (cat)
| | | |
|
Moderately inactive
|
0.05
|
0.17
|
0.57
|
|
Moderately active
|
0.03
|
0.01
|
0.38
|
|
Active
|
0.43
|
0.73
|
0.76
|
|
Red meat
|
0.02
|
0.08
|
0.90
|
|
Alcohol
|
0.23
|
0.27
|
0.40
|
|
Folate
|
0.91
|
0.0006
|
0.72
|
|
Smoking
| | | |
|
Former
|
0.77
|
0.72
|
0.72
|
|
Current
|
0.15
|
0.20
|
0.93
|
|
Age at menarche (cat)
| | | |
|
12–14
|
0.53
|
0.03
|
0.16
|
|
≥15
|
0.20
|
0.41
|
0.88
|
|
Age at menopause
|
0.45
|
0.73
|
0.25
|
|
Menopausal state
|
0.002
|
0.25
|
0.78
|
|
Ever pill
|
0.21
|
0.62
|
0.18
|
|
Ever HRT
|
0.34
|
0.09
|
0.60
|
|
ER status
|
0.42
|
0.14
|
0.39
|
|
PR status
|
0.76
|
0.44
|
0.08
|
- To demonstrate that there was no batch effect for the chip, we report the smallest p value for the association between the PCs and all chips.
- Italics = p-values <0.01
