Table 3 Association between global methylation and breast cancer risk by CpG genomic feature per 1 SD in EPIC

All

Including all probes

408,749

0.61

(0.47–0.80)

0.0004

Excluding SNP probes

360,342

0.62

(0.47–0.81)

0.0004

CpG island

Island

124,962

0.76

(0.57–0.99)

0.04

Shores

98,890

0.72

(0.55–0.93)

0.01

Shelves

38,755

0.50

(0.37–0.68)

8.93 × 10⁻⁶

None

146,142

0.50

(0.38–0.68)

7.44 × 10⁻⁶

Gene region feature category

TSS1500

59,494

0.70

(0.53–0.92)

0.01

TSS200

43,506

0.92

(0.69–1.24)

0.60

5′UTR

36,778

0.72

(0.54–0.95)

0.02

1st exon

19,024

0.85

(0.65–1.12)

0.25

Promoter

82,006

0.92

(0.64–1.32)

0.66

Gene body

138,499

0.51

(0.38–0.69)

1.58 × 10⁻⁵

UTR3

15,065

0.40

(0.29–0.57)

2.90 × 10⁻⁷

Intergenic

96,383

0.57

(0.43–0.75)

6.86 × 10⁻⁵