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Table 1 Association between average methylation and breast cancer risk in EPIC and NOWAC

From: Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

   Cases
(n)
Controls
(n)
OR (95 % CI) p value
EPIC
 By quartile Q1 [0.529–0.546] 75 41 1.00   
  Q2 [0.546–0.549] 31 40 0.46 (0.25–0.84) 0.01
  Q3 [0.549–0.551] 30 40 0.40 (0.21–0.76) 0.005
  Q4 [0.551–0.560] 26 41 0.34 (0.18–0.66) 0.001
  Per 1 SD 162 162 0.61 (0.46–0.80) 0.0003
 Time to diagnosis <3.8 81 81 0.66 (0.46–0.94) 0.02
 (years) >3.8 81 81 0.54 (0.35–0.83) 0.005
     p het = 0.483   
 ER status Negative 18 18 0.49 (0.20–1.24) 0.13
  Positive 56 56 0.59 (0.36–0.96) 0.03
     p het = 0.725   
NOWAC
 By quartile Q1 [0.527–0.538] 45 42 1.00   
  Q2 [0.538–0.540] 32 42 0.74 (0.41–1.34) 0.32
  Q3 [0.540–0.543] 46 42 1.04 (0.59–1.85) 0.88
  Q4 [0.543–0.551] 45 42 0.99 (0.56–1.76) 0.98
  Per 1 SD 168 168 1.03 (0.82–1.30) 0.81
 Time to diagnosis <2.1 84 84 0.92 (0.66–1.29) 0.62
 (years) >2.1 84 84 1.15 (0.83–1.60) 0.41
     p het = 0.351   
 ER status Negative 28 28 0.80 (0.48–1.32) 0.38
  Positive 130 130 1.10 (0.84–1.44) 0.50
     p het = 0.276