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Fig. 7 | Clinical Epigenetics

Fig. 7

From: Colorimetric detection of both total genomic and loci-specific DNA methylation from limited DNA inputs

Fig. 7

Electrochemical detection of GSTP1 methylation in urine DNA. a Conceptual schematic of the electrochemical detection of HRP oxidized TMB (TMB ox ). Photo of disposable SPCE is shown. On the electrode surface, TMB ox is reduced back to TMB red . The resulting current is proportional to the amount of TMB ox . b Current measurements of the four patient samples. Blue: post-MBD enrichment. Red: input control. c Comparison of methylation scores for patient samples determined electrochemically (blue) and by absorbance (red). Error bars represent SD, n = 3

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