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Fig. 4 | Clinical Epigenetics

Fig. 4

From: DNA methylation profiling of the X chromosome reveals an aberrant demethylation on CXCR3 promoter in primary biliary cirrhosis

Fig. 4

a Chromosomal sequence location of the region of the UBE2A promoter that was analyzed by bisulfite sequencing. This region contains 20 CpG sites (vertical bars) within a 542 bp region upstream of the transcription start site as shown. b Representative bisulfite sequencing data from CD4+ cells of a PBC sample and a normal control, respectively. Each circle represents a CpG site, and each line represents an individually sequenced clone. Filled circles represent methylated sites (protected from bisulfite conversion), while unfilled circles represent unmethylated CpG sites (converted). c Mean methylation level was calculated for each individual CpG site within the UBE2A promoter region for all clones for PBC (n = 20) versus healthy (n = 20) CD4+ cells. d Overall percentage of methylation of UBE2A was determined by the total number of methylated sites out of the total CpG sites in all clones and graphed as mean ± SD for PBC (n = 20) versus healthy (n = 20) CD4+ cells. *p < 0.05

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Clinical Epigenetics

ISSN: 1868-7083

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