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Table 3 Association between epigenetic/genetic alterations of the UNC5C gene and clinicopathological features in gastric cancers

From: Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability

 

UNC5 Methylation Status—% (No.)

4q LOH Status—% (No.)

UNC5C Alteration Status—% (No.)

Unmethylation

Methylation

P

Not informative

Negative

Positive

P

Not informative

Negative

Positive

Positive

P

Total

Methylation alone

LOH alone

Both

(n = 67)

(n = 31)

(n = 19)

(n = 56)

(n = 23)

(n = 19)

(n = 39)

(n = 40)

(n = 17)

(N = 13)

(N = 10)

Age

Mean age (SD)

64.3 (12.6)

66.7 (9.7)

0.49a

60.2 (12.6)

65.4 (12.3)

68.3 (8.2)

0.42a

60.2 (12.6)

64.8 (13.3)

67.8 (8.9)

67.0 (10.0)

67.2 (8.3)

69.8 (8.2)

0.36a

Gender

Female

36 (24)

32 (10)

0.73b

47 (9)

36 (20)

22 (5)

0.23b

47 (9)

33 (13)

30 (12)

41 (7)

38 (5)

0 (0)

0.75b

Male

64 (43)

68 (21)

 

53 (10)

64 (36)

78 (18)

 

53 (10)

67 (26)

70 (28)

59 (10)

62 (8)

100 (10)

 

Histology

Diff

48 (32)

52 (16)

0.72b

58 (11)

39 (22)

65 (15)

0.036b

58 (11)

41 (16)

52 (21)

35 (6)

54 (7)

80 (8)

0.31b

Undiff

520(35)

48 (15)

 

42 (8)

61 (34)

35 (8)

 

42 (8)

59 (23)

48 (19)

65 (11)

46 (6)

20 (2)

 

Stage

IA/IB

22 (15)

10 (3)

0.17b

26 (5)

21 (12)

4 (1)

0.29b

26 (5)

28 (11)

5 (2)

6 (1)

8 (1)

0 (0)

0.03b

IIA/IIB

33 (22)

23 (7)

 

21 (4)

29 (16)

39 (9)

 

21 (4)

33 (13)

30 (12)

18 (3)

38 (5)

40 (4)

 

IIIA/IIIB/IIIC

31 (21)

52 (16)

 

37 (7)

38 (21)

39 (9)

 

37 (7)

28 (11)

48 (19)

59 (10)

31 (4)

50 (5)

 

IV

13 (9)

16 (5)

 

16 (3)

13 (7)

17 (4)

 

16 (3)

10 (4)

18 (7)

18 (3)

23 (3)

10 (1)

 

T

T1a/1b

18 (12)

6 (2)

0.20b

21 (4)

16 (9)

4 (1)

0.49b

21 (4)

21 (8)

5 (2)

6 (1)

8 (1)

0 (0)

0.15b

T2

16 (11)

10 (3)

 

11 (2)

14 (8)

17 (4)

 

11 (2)

18 (7)

13 (5)

6 (1)

15 (2)

20 (2)

 

T3

22 (15)

39 (12)

 

26 (5)

25(14)

35 (8)

 

26 (5)

23 (9)

33 (13)

29 (5)

23 (3)

50 (5)

 

T4a/4b

43 (29)

45 (14)

 

42 (8)

45 (25)

43 (10)

 

42 (8)

38 (15)

50 (20)

59 (10)

54 (7)

30 (3)

 

N

N0

31 (21)

16 (5)

0.06b

32 (6)

32 (18)

9 (2)

0.19b

32 (6)

38 (15)

13 (5)

18 (3)

15 (2)

0 (0)

0.03b

N1

39 (26)

26 (8)

 

42 (8)

30 (17)

39 (9)

 

42 (8)

33 (13)

33 (13)

24 (4)

38 (5)

40 (4)

 

N2

19 (13)

35 (11)

 

11 (2)

25 (14)

38 (8)

 

11 (2)

21 (8)

35 (14)

35 (6)

31 (4)

40 (4)

 

N3

10 (7)

23 (7)

 

16 (3)

13 (7)

17 (4)

 

16 (3)

8 (3)

20 (8)

24 (4)

15 (2)

20 (2)

 

Distant metastasis

Negative

87 (58)

84 (26)

0.72b

84 (16)

88 (49)

83 (19)

0.57b

84 (16)

90 (35)

39

94 (16 )

100 (13)

100 (10)

0.35b

Positive

13 (9)

16 (5)

 

16 (3)

13 (7)

17 (4)

 

16 (3)

10 (4)

0

6 (1)

0 (0)

0 (0)

 

MSI

MSI

7 (5)

26 (8)

0.013b

21 (4)

14 (8)

4 (1)

0.21b

21 (4)

10 (4)

5

24 (4)

0 (0)

10 (1)

0.75b

Non-MSI

93 (62)

74 (23)

 

79 (15)

86 (48)

96 (22)

 

79 (15)

90 (35)

35

76 (13)

100 (13)

90 (9)

 

LOH Ratio

Mean ratio (SD)

0.21 (0.28)

0.31 (0.35)

0.19a

0.32 (0.36)

0.15 (0.25)

0.40 (0.29)

<0.0001a

0.32 (0.36)

0.11 (0.22)

0.33 (0.30)

0.24 (0.29)

0.37 (0.25)

0.45 (0.36)

0.0001a

CIN*

Positive

49 (32)

58 (18)

0.42b

58 (11)

37 (20)

83 (19)

0.0003b

58 (11)

30 (11)

28

53 (9 )

85 (11)

80 (8)

0.004b

Negative

51 (33)

42 (13)

 

42 (8)

63 (34)

17 (4)

 

42 (8)

70 (26)

12

47 (8)

15 (2)

20 (2)

 

KRAS/BRAF/PIK3CA

Mutant

6 (4)

13 (4)

0.24b

5 (1)

13 (7)

0 (0)

0.08b

5 (1)

8 (3)

4

24 (4)

0 (0)

0 (0)

0.72b

Wild

94 (63)

87 (27)

 

95 (18)

88 (49)

100 (23)

 

95 (18)

92 (36)

36

76 (13)

100 (13)

100 (10)

 

H.pyroli

Positive

72 (48)

71 (22)

0.95b

68 (13)

70 (39)

78 (18)

0.44b

68 (13)

67 (26)

9

24 (4)

15 (2)

30 (3)

0.28b

Negative

28 (19)

29 (9)

 

32 (6)

30 (17)

22 (5)

 

32 (6)

33 (13)

31

76 (13)

85 (11)

70 (7)

 
  1. *Two cases are not informative of CIN status
  2. a P value were calculated between unmethylation and methylation, 4qLOH negative and positive, and UNC5C alteration negative and positive(total) by Wilcoxon/Kruskal–Wallis test
  3. b P values were calculated by Pearson’s chi-square test
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Clinical Epigenetics

ISSN: 1868-7083

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