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Table 2 Association between epigenetic/genetic alterations of the DCC gene and clinicopathological features in gastric cancers

From: Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability

 

DCC Methylation Status—% (No.)

18q LOH Status—% (No.)

DCC Alteration Status—% (No.)

Unmethylation

Methylation

P

Not informative

Negative

Positive

P

Not informative

Negative

Positive

Positive

P

Total

Methylation alone

LOH alone

Both

(n = 54)

(n = 44)

(n = 15)

(n = 47)

(n = 36)

(n = 15)

(n = 25)

(n = 58)

(n = 22)

(n = 19)

(n = 17)

Age

Mean age (SD)

63.6 (12.5)

67.0 (10.7)

0.48a

68.9 (11.4)

64.8 (11.4)

63.9 (12.4)

0.76a

68.9 (11.4)

63.5 (12.9)

64.8 (11.3)

66.3 (9.5)

60.7 (12.7)

67.4 (11.4)

0.98a

Gender

Female

39 (21)

30 (13)

0.33b

40 (6)

38 (18)

28 (10)

0.32b

40 (6)

44 (11)

29 (17)

32 (7)

32 (6)

24 (4)

0.19b

Male

61 (23)

70 (31)

 

60 (9)

62 (29)

72 (26)

 

60 (9)

56 (14)

71 (41)

68 (15)

68 (13)

76 (13)

 

Histology

Diff

41 (22)

59 (26)

0.071b

47 (7)

55 (26)

42 (15)

0.22b

47 (7)

52 (13)

48 (28)

59 (13)

32 (6)

53 (9)

076b

Undiff

59 (32)

41 (18)

 

53 (8)

45 (21)

58 (21)

 

53 (8)

48 (12)

52 (30)

41 (9)

68 (13)

47 (8)

 

Stage

IA/IB

20 (11)

16 (7)

0.83b

13 (2)

19 (9)

19 (7)

0.15b

13 (2)

24 (6)

17 (10)

14 (3)

21 (4)

18 (3)

0.70b

IIA/IIB

26 (14)

34 (15)

 

27 (4)

30 (14)

31 (11)

 

27 (4)

24 (6)

33 (19)

36 (8)

32 (6)

29 (5)

 

IIIA/IIIB/IIC

39 (21)

36 (16)

 

53 (8)

43 (20)

25 (9)

 

53 (8)

40 (10)

33 (19)

45 (10)

26 (5)

24 (4)

 

IV

15 (8)

14 (6)

 

7 (1)

9 (4)

25 (9)

 

7 (1)

12 (3)

17 (10)

5 (1)

21 (4)

29 (5)

 

T

T1a/1b

15 (8)

14 (6)

0.24b

7 (1)

17 (8)

14 (5)

0.94b

7 (1)

16 (4)

16 (9)

18 (4)

21 (4)

6 (1)

0.54b

T2

13 (7)

16 (7)

 

13 (2)

15 (7)

14 (5)

 

13 (2)

16 (4)

14 (8)

14 (3)

11 (2)

18 (3)

 

T3

20 (11)

36 (16)

 

33 (5)

28 (13)

25 (9)

 

33 (5)

16 (4)

31 (18)

41 (9)

16 (3)

35 (6)

 

T4a/b

52 (28)

34 (15)

 

47 (7)

40 (19)

47 (17)

 

47 (7)

52 (13)

40 (23)

27 (6)

53 (10)

41 (7)

 

N

N0

30 (16)

23 (10)

0.66b

20 (3)

28 (13)

28 (10)

0.29b

20 (3)

32 (8)

26 (15)

23 (5)

32 (6)

24 (4)

0.19b

N1

37 (20)

32 (14)

 

47 (7)

38 (18)

25 (9)

 

47 (7)

44 (11)

28 (16)

32 (7)

26 (5)

24 (4)

 

N2

20 (11)

30 (13)

 

20 (3)

26 (12)

25 (9)

 

20 (3)

20 (5)

28 (16)

32 (7)

21 (4)

29 (5)

 

N3

13 (7)

16 (7)

 

13 (2)

9 (4)

22 (8)

 

13 (2)

4 (1)

19 (11)

14 (3)

21 (4)

24 (4)

 

Distant metastasis

Negative

85 (46)

86 (38)

0.87b

93 (14)

91 (43)

75 (27)

0.041b

93 (14)

88 (22)

83 (48)

95 (21)

79 (15)

71 (12)

0.55b

Positive

15 (8)

14 (6)

 

7 (1)

9 (4)

25 (9)

 

7 (1)

12 (3)

17 (10)

5 (1)

21 (4)

29 (5)

 

MSI status

MSI

6 (3)

23 (10)

0.013b

33 (5)

9 (4)

11 (4)

0.69b

33 (5)

4 (1)

12 (7)

14 (3)

0 (0)

24 (4)

0.25b

Non-MSI

94 (51)

77 (34)

 

67 (10)

91 (43)

89 (32)

 

67 (10)

96 (24)

88 (51)

86 (19)

100 (19)

76 (13)

 

LOH ratio

Mean ratio (SD)

0.23 (0.30)

0.26 (0.31)

0.55a

0.22 (0.29)

0.10 (0.15)

0.44 (0.36)

<0.0001a

0.22 (0.29)

0.05 (0.10)

0.33 (0.33)

0.16 (0.18)

0.44 (0.34)

0.44 (0.39)

<0.0001a

CIN*

Positive

46 (25)

57 (25)

0.39b

47 (7)

38 (18)

74 (25)

0.0017b

47 (7)

24 (6)

66 (37)

55 (12)

76 (13)

71 (12)

0.0005b

Negative

54 (27)

43 (19)

 

53 (8)

62 (29)

26 (9)

 

53 (8)

76 (19)

34 (19)

45 (10)

24 (4)

29 (5)

 

KRAS/BRAF/PIK3CA

Mutant

6 (3)

11 (5)

0.30b

27 (4)

6 (3)

3 (1)

0.45b

27 (4)

4 (1)

5 (3)

9 (2)

5 (1)

0 (0)

0.82b

Wild

94 (51)

89 (38)

 

73 (11)

94 (44)

97 (35)

 

73 (11)

96 (24)

95 (55)

91 (20)

95 (18)

100 (17)

 

H.pyroli

Positive

72 (39)

70 (31)

0.85b

80 (12)

66 (31)

75(27)

0.37b

80 (12)

60 (15)

74 (43)

73 (16)

79 (15)

71 (12)

0.20b

Negative

28 (15)

30 (13)

 

20 (3)

34(16)

25 (9)

 

20 (3)

40 (10)

26 (15)

27 (6)

21 (4)

29 (5)

 
  1. *Two cases are not informative of CIN status
  2. a P value were calculated between unmethylation and methylation, 18qLOH negative and positive, and DCC alteration negative and positive(total) by Wilcoxon/Kruskal–Wallis test
  3. b P values were calculated between unmethylation and methylation, 18qLOH negative and positive, and DCC alteration negative and positive(total) by Piason's chi-square test
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