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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer

Fig. 2

Cumulative incidence of invasive breast cancer diagnosis stratified by the median methylation in DCIS of each CpG into high or low methylation groups. a Increased methylation in DCIS of a CpG in the south shore of a HOXB13 promoter CpG island is associated with invasive breast cancer outcome (HR = 1.86, 95 % CI, 1.37–2.53) (high-methylation beta-value range, 0.14–0.71, low-methylation beta-value range, 0.03 - 0.13). b Increased methylation in DCIS of a gene body CpG island site in EN1 is associated with invasive breast cancer outcome (HR = 3.61, 95 % CI, 1.90–6.88) (high-methylation beta-value range, 0.27–0.58, low-methylation beta-value range, 0.069 - 0.27). c Increased methylation in DCIS of a gene body CpG island site in DLX4 is associated with invasive breast cancer outcome (HR = 1.92, 95 % CI, 1.37–2.69) (high-methylation beta-value range, 0.31–0.78, low-methylation beta-value range, 0.078–0.31). d Increased methylation in DCIS of a CpG site in the south shore of a CpG island in the 5′’UTR of TBX15 is associated with invasive breast cancer outcome (HR = 2.12, 95 % CI, 1.43–3.15) (high-methylation beta-value range, 0.42–0.82, low-methylation beta-value range, 0.13 - 0.39)

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