Fig. 2From: DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancerCumulative incidence of invasive breast cancer diagnosis stratified by the median methylation in DCIS of each CpG into high or low methylation groups. a Increased methylation in DCIS of a CpG in the south shore of a HOXB13 promoter CpG island is associated with invasive breast cancer outcome (HR = 1.86, 95 % CI, 1.37–2.53) (high-methylation beta-value range, 0.14–0.71, low-methylation beta-value range, 0.03 - 0.13). b Increased methylation in DCIS of a gene body CpG island site in EN1 is associated with invasive breast cancer outcome (HR = 3.61, 95 % CI, 1.90–6.88) (high-methylation beta-value range, 0.27–0.58, low-methylation beta-value range, 0.069 - 0.27). c Increased methylation in DCIS of a gene body CpG island site in DLX4 is associated with invasive breast cancer outcome (HR = 1.92, 95 % CI, 1.37–2.69) (high-methylation beta-value range, 0.31–0.78, low-methylation beta-value range, 0.078–0.31). d Increased methylation in DCIS of a CpG site in the south shore of a CpG island in the 5′’UTR of TBX15 is associated with invasive breast cancer outcome (HR = 2.12, 95 % CI, 1.43–3.15) (high-methylation beta-value range, 0.42–0.82, low-methylation beta-value range, 0.13 - 0.39)Back to article page