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Table 2 Cellular miRs differentially expressed in human diabetic and healthy tissue, or in human cell lines exposed to normoglycemic and hyperglycemic conditions

From: Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes

MiRs

Expression levels

mRNA targets

Cell types

Refs

miR classification

Diabetic retinopathy

 

miR-146a

Down

Fibronectin

HUVECs

[103]

I, A, O

miR-146b-3p

Down

ADA2

Vitreous of diabetes patients, macrophages

[79]

O

miR-200b

Down

VEGF

HUVEC

[104]

O, A

miR-195

Up

SIRT1

HRECs, HMECs

[105]

A, O

Diabetic nephropathy

 

miR-192

Up

ZEB 1/2

Glomeruli from renal biopsies

[106]

O

miR-377

Up

Pak1, Sod1/2

NHMCs

[107]

O, A

miR-29a/b/c

Down

Col1, Col4

h. conditionally immortalized podocyte

[108]

O

miR-21

Up

PTEN, RAS40

hMCs

[91]

O, I, A

 

Up

TIMP3

human kidney biopsy

[92]

 

miR-155

Up

 

h. kidney biopsy, HRGECs

[109]

I, O, A

miR-146a

Up

 

h. kidney biopsy, HRGECs

[109]

I, A, O

miR-215

Down

SIP1/ZEB2

h. conditionally immortalized podocytes

[110]

O

miR-135a

Up

TRPC1

kidney tissues, HMC

[111]

O

Macrovascular diabetic complications

 

miR-16

Down

Cox-2

THP-1 monocytes

[112]

O

miR-503

Up

Ccne1-Cdc25A

HUVEC, HMVEC

[102]

O, A

miR-133

Down

Rho-A, Cdc42

h. embryos/fetuses cardiac cells

[113]

I, A

miR-223

Up

Glut4

Left ventricular biopsies

[114]

I, O, A

miR-221

Up

C-kit

HUVEC

[115]

O, A

miR-492

Down

Resistin

HUVEC

[116]

O, A

  1. H, human; HMC, immortalized human mesangial cell; HRECs, HMECs, human retinal and dermal microvascular endothelial cells; HRGECs, human renal glomerular endothelial cells; NHMCs, normal human mesangial cells. I, inflammamiRs; O, oncomiRs; A, angiomiRs. This classification is based on the amount of relative literature, and some miRNAs can be classified in more than one group