From: Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes
MiRs | Expression levels | mRNA targets | Cell types | Refs | miR classification |
---|---|---|---|---|---|
Diabetic retinopathy | Â | ||||
miR-146a | Down | Fibronectin | HUVECs | [103] | I, A, O |
miR-146b-3p | Down | ADA2 | Vitreous of diabetes patients, macrophages | [79] | O |
miR-200b | Down | VEGF | HUVEC | [104] | O, A |
miR-195 | Up | SIRT1 | HRECs, HMECs | [105] | A, O |
Diabetic nephropathy | Â | ||||
miR-192 | Up | ZEB 1/2 | Glomeruli from renal biopsies | [106] | O |
miR-377 | Up | Pak1, Sod1/2 | NHMCs | [107] | O, A |
miR-29a/b/c | Down | Col1, Col4 | h. conditionally immortalized podocyte | [108] | O |
miR-21 | Up | PTEN, RAS40 | hMCs | [91] | O, I, A |
 | Up | TIMP3 | human kidney biopsy | [92] |  |
miR-155 | Up | Â | h. kidney biopsy, HRGECs | [109] | I, O, A |
miR-146a | Up | Â | h. kidney biopsy, HRGECs | [109] | I, A, O |
miR-215 | Down | SIP1/ZEB2 | h. conditionally immortalized podocytes | [110] | O |
miR-135a | Up | TRPC1 | kidney tissues, HMC | [111] | O |
Macrovascular diabetic complications | Â | ||||
miR-16 | Down | Cox-2 | THP-1 monocytes | [112] | O |
miR-503 | Up | Ccne1-Cdc25A | HUVEC, HMVEC | [102] | O, A |
miR-133 | Down | Rho-A, Cdc42 | h. embryos/fetuses cardiac cells | [113] | I, A |
miR-223 | Up | Glut4 | Left ventricular biopsies | [114] | I, O, A |
miR-221 | Up | C-kit | HUVEC | [115] | O, A |
miR-492 | Down | Resistin | HUVEC | [116] | O, A |