Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes

Clinical Epigenetics

Table 2 Cellular miRs differentially expressed in human diabetic and healthy tissue, or in human cell lines exposed to normoglycemic and hyperglycemic conditions

MiRs	Expression levels	mRNA targets	Cell types	Refs	miR classification
Diabetic retinopathy
miR-146a	Down	Fibronectin	HUVECs	[103]	I, A, O
miR-146b-3p	Down	ADA2	Vitreous of diabetes patients, macrophages	[79]	O
miR-200b	Down	VEGF	HUVEC	[104]	O, A
miR-195	Up	SIRT1	HRECs, HMECs	[105]	A, O
Diabetic nephropathy
miR-192	Up	ZEB 1/2	Glomeruli from renal biopsies	[106]	O
miR-377	Up	Pak1, Sod1/2	NHMCs	[107]	O, A
miR-29a/b/c	Down	Col1, Col4	h. conditionally immortalized podocyte	[108]	O
miR-21	Up	PTEN, RAS40	hMCs	[91]	O, I, A
	Up	TIMP3	human kidney biopsy	[92]
miR-155	Up		h. kidney biopsy, HRGECs	[109]	I, O, A
miR-146a	Up		h. kidney biopsy, HRGECs	[109]	I, A, O
miR-215	Down	SIP1/ZEB2	h. conditionally immortalized podocytes	[110]	O
miR-135a	Up	TRPC1	kidney tissues, HMC	[111]	O
Macrovascular diabetic complications
miR-16	Down	Cox-2	THP-1 monocytes	[112]	O
miR-503	Up	Ccne1-Cdc25A	HUVEC, HMVEC	[102]	O, A
miR-133	Down	Rho-A, Cdc42	h. embryos/fetuses cardiac cells	[113]	I, A
miR-223	Up	Glut4	Left ventricular biopsies	[114]	I, O, A
miR-221	Up	C-kit	HUVEC	[115]	O, A
miR-492	Down	Resistin	HUVEC	[116]	O, A

H, human; HMC, immortalized human mesangial cell; HRECs, HMECs, human retinal and dermal microvascular endothelial cells; HRGECs, human renal glomerular endothelial cells; NHMCs, normal human mesangial cells. I, inflammamiRs; O, oncomiRs; A, angiomiRs. This classification is based on the amount of relative literature, and some miRNAs can be classified in more than one group

ISSN: 1868-7083