CLDN18
|
NM_016369.3
|
Claudin 18
|
100
|
Intercellular adhesion molecule responsible for tight junction strand formation [77]
|
KRT85
|
NM_002283.3
|
Keratin 85
|
100
|
Component of intermediate filament in epithelial cells contributing to cell-cell adhesion [78–80]
|
MIR127
|
NR_029696.1
|
microRNA 127
|
100
|
Regulator of cell proliferation and senescence [81]
|
MIR433
|
NR_029966.1
|
microRNA 433
|
100
|
Deregulated in gastric cancer, regulator of cell migration and drug response [82, 83]
|
HOXD3
|
NM_006898.4
|
HomeoboxD3
|
100
|
Proangiogenic transcription factor [84]
|
MIR23B
|
NR_029664.1
|
microRNA 23b
|
92
|
Involved in cytoskeleton modelling, motility and metastasis [85–88]
|
CCDC8
|
NM_032040.4
|
Coil coiled domain containing 8
|
73
|
Mutated in patients with 3 M syndrome [70]. Loss is associated with genomic instability and aneuploidy [75].
|
KRT83
|
NM_002282.3
|
Keratin 83
|
84
|
Component of intermediate filament, contributes to cell to cell adhesion [78, 80]
|
HOXB13
|
NM_006361.5
|
Homeobox B13
|
80
|
TSG for prostate cancer, inhibits androgen mediated signalling [89]
|
ABCB1
|
NM_000927.4
|
ATP-binding cassette sub-family B member 1
|
80
|
Controls efflux of substances across plasma membranes, associated with multidrug resistance [90]
|
PENK
|
NM_006211.3
|
Proenkephalin
|
80
|
Promotes RNA splicing in osteoblasts and neural cells, plays role in bone development [91]
|
MST1R
|
NM_002447.2
|
Macrophage stimulating 1 receptor
|
78
|
Involved in intracellular signalling cascades leading to cellular growth, motility and invasion [92]
|
BNC1
|
NM_001717.3
|
Basonuclin 1
|
71
|
Zink finger transcription factor, regulator of EMT [68]
|
PCDH8
|
NM_002590.3
|
Procadhern 8
|
73
|
Helps in cell to cell adhesion [93]
|
STAT3
|
NM_139276.2
|
Signal transducer and activator of transcription 3
|
67
|
Involved in embryonic stem cell regulation, somatic cell growth [94–96]
|
BVES
|
NM_007073.4
|
Blood vessel epicardial substance
|
64
|
Involved in inter-cellular interaction and cell adhesion [97]
|
TNFRSF10D
|
NM_003840.4
|
Tumour Necrosis Factor receptor superfamily 10 D
|
60
|
Member of TNF (Tumour Necrosis Factor) receptor superfamily, promotes apoptosis in cancer cells [98]
|
CLDN6
|
NM_021195.4
|
Claudin 6
|
55
|
Intercellular adhesion molecules responsible for tight junction strand formation, its epigenetic silencing is associated with migration and invasiveness of breast cancer [77, 99]
|
HOXD10
|
NM_002148.3
|
Homeobox D10
|
55
|
Maintain epithelial cell plasticity and contributes to stability of extracellular matrix [100]
|
GALNT9
|
NM_001122636.1
|
N-acetyl galactosaminyl transferase 9
|
55
|
Catalyzes O-glycosylation [53, 101]
|
WIF1
|
NM_007191.4
|
Wnt inhibitory factor-1 gene
|
53
|
Inhibitor of Wnt-signalling [102, 103]
|