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Table 3 Association between packyears and cessation time and methylation of significant CpG sites

From: Tobacco smoking is associated with methylation of genes related to coronary artery disease

 

Packyearsa

 

Cessation timeb

CpG site

Estimate (se)

p-value

Estimate (se)

p-value

cg24908166

−0.001 (0.001)

0.24

−0.003 (0.001)

0.02

cg12324353

−0.003 (0.001)

2.3 × 10−3

0.002 (0.001)

0.05

cg03725309

−0.002 (0.002)

0.15

0.004 (0.002)

0.02

cg00980784

−0.003 (0.001)

0.01

−0.001 (0.001)

0.69

cg13916835

−0.002 (0.002)

0.14

0.002 (0.002)

0.24

cg09469355

−0.003 (0.001)

0.04

−0.006 (0.001)

6.0 × 10−5

cg05603985

−0.002 (0.001)

0.03

0.004 (0.001)

1.2 × 10−3

cg04324276

−0.002 (0.001)

0.22

0.002 (0.001)

0.17

cg25468516

−0.001 (0.001)

0.20

0.003 (0.001)

0.06

cg22907952

−0.003 (0.001)

1.8 × 10−3

0.002 (0.001)

0.12

cg15474579

−0.004 (0.001)

0.02

0.005 (0.001)

1.5 × 10−3

cg20496896

0.002 (0.002)

0.12

−0.003 (0.001)

3.9 × 10−3

cg09397246

0.001 (0.002)

0.35

−0.001 (0.002)

0.38

cg26405020

0.002 (0.001)

0.06

−0.002 (0.001)

0.05

cg18236066

−0.002 (0.001)

0.18

0.003 (0.001)

0.04

  1. Bonferroni-corrected threshold 3.3 × 10−3
  2. aIn current smokers, per 10 packyears, adjusted for age, sex, BMI, Houseman estimates, batch effects
  3. bIn former smokers, per 10 years of smoking cessation, adjusted for age, sex, BMI, Houseman estimates, batch effects