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Table 2 Significant associations between tobacco smoking and methylation of CAD genes

From: Tobacco smoking is associated with methylation of genes related to coronary artery disease

 

Current-Never

Adjusted model

Current-Former

Adjusted model

CpG site

Estimate (se)

p-value

Estimate (se)

p-value

Estimate (se)

p-value

Estimate (se)

p-value

cg24908166

−0.014 (0.003)

1.1 × 10−7

−0.015 (0.003)

1.6 × 10−8

−0.006 (0.002)

0.02

−0.007 (0.003)

0.01

cg12324353

−0.012 (0.003)

1.3 × 10−7

−0.012 (0.002)

3.5 × 10−7

−0.007 (0.002)

2.8 × 10−3

−0.007 (0.002)

2.1 × 10−3

cg03725309

−0.024 (0.005)

2.0 × 10−7

−0.022 (0.005)

3.8 × 10−6

−0.017 (0.004)

4.2 × 10−5

−0.016 (0.004)

1.2 × 10−4

cg00980784

−0.015 (0.003)

2.5 × 10−7

−0.014 (0.003)

3.5 × 10−6

−0.015 (0.003)

2.4 × 10−8

−0.015 (0.003)

8.6 × 10−8

cg13916835

−0.021 (0.004)

3.0 × 10−7

−0.021 (0.004)

1.3 × 10−6

−0.013 (0.004)

1.5 × 10−3

−0.013 (0.004)

1.9 × 10−3

cg09469355

−0.017 (0.003)

7.7 × 10−7

−0.017 (0.003)

8.5 × 10−7

−0.015 (0.003)

3.8 × 10−6

−0.015 (0.003)

1.6 × 10−6

cg05603985

−0.014 (0.003)

8.4 × 10−7

−0.013 (0.003)

3.6 × 10−5

−0.014 (0.003)

1.3 × 10−7

−0.014 (0.003)

2.4 × 10−7

cg04324276

−0.015 (0.003)

3.2 × 10−6

−0.015 (0.003)

1.2 × 10−5

−0.010 (0.003)

2.4 × 10−4

−0.010 (0.003)

5.2 × 10−4

cg25468516

−0.015 (0.003)

3.6 × 10−6

−0.014 (0.003)

3.0 × 10−5

0.011 (0.003)

2.3 × 10−4

0.012 (0.003)

1.2 × 10−4

cg22907952

−0.011 (0.002)

4.5 × 10−6

−0.010 (0.003)

6.9 × 10−5

−0.007 (0.002)

1.1 × 10−3

−0.007 (0.002)

1.5 × 10−3

cg15474579

−0.017 (0.004)

5.0 × 10−6

−0.013 (0.004)

5.2 × 10−4

−0.016 (0.003)

2.0 × 10−6

−0.016 (0.003)

7.6 × 10−6

cg20496896

0.012 (0.003)

6.7 × 10−6

0.013 (0.003)

4.6 × 10−6

0.005 (0.002)

0.06

0.005 (0.002)

0.03

cg09397246

0.018 (0.004)

1.0 × 10−5

0.018 (0.004)

3.1 × 10−5

0.017 (0.003)

5.6 × 10−7

0.017 (0.003)

1.9 × 10−6

cg26405020

0.014 (0.003)

1.2 × 10−5

0.014 (0.003)

1.4 × 10−5

0.008 (0.003)

2.6 × 10−3

0.007 (0.003)

8.2 × 10−3

cg18236066

−0.014 (0.003)

1.3 × 10−5

−0.015 (0.003)

2.5 × 10−5

−0.011 (0.003)

1.4 × 10−4

−0.011 (0.003)

1.8 × 10−4

  1. Bonferroni-corrected threshold 1.4 × 10−5
  2. Current-Never: adjusted for age, sex, BMI, Houseman estimates, batch effects
  3. Adjusted model: current-never, adjusted for age, sex, BMI, Houseman estimates, batch effects, systolic blood pressure, total cholesterol, triglycerides, daily alcohol intake, type 2 diabetes mellitus
  4. Current-Former: adjusted for age, sex, BMI, Houseman estimates, batch effects
  5. Adjusted model: current-former, adjusted for age, sex, BMI, Houseman estimates, batch effects, systolic blood pressure, total cholesterol, triglycerides, daily alcohol intake, type 2 diabetes mellitus