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Table 2 Significant associations between tobacco smoking and methylation of CAD genes

From: Tobacco smoking is associated with methylation of genes related to coronary artery disease

  Current-Never Adjusted model Current-Former Adjusted model
CpG site Estimate (se) p-value Estimate (se) p-value Estimate (se) p-value Estimate (se) p-value
cg24908166 −0.014 (0.003) 1.1 × 10−7 −0.015 (0.003) 1.6 × 10−8 −0.006 (0.002) 0.02 −0.007 (0.003) 0.01
cg12324353 −0.012 (0.003) 1.3 × 10−7 −0.012 (0.002) 3.5 × 10−7 −0.007 (0.002) 2.8 × 10−3 −0.007 (0.002) 2.1 × 10−3
cg03725309 −0.024 (0.005) 2.0 × 10−7 −0.022 (0.005) 3.8 × 10−6 −0.017 (0.004) 4.2 × 10−5 −0.016 (0.004) 1.2 × 10−4
cg00980784 −0.015 (0.003) 2.5 × 10−7 −0.014 (0.003) 3.5 × 10−6 −0.015 (0.003) 2.4 × 10−8 −0.015 (0.003) 8.6 × 10−8
cg13916835 −0.021 (0.004) 3.0 × 10−7 −0.021 (0.004) 1.3 × 10−6 −0.013 (0.004) 1.5 × 10−3 −0.013 (0.004) 1.9 × 10−3
cg09469355 −0.017 (0.003) 7.7 × 10−7 −0.017 (0.003) 8.5 × 10−7 −0.015 (0.003) 3.8 × 10−6 −0.015 (0.003) 1.6 × 10−6
cg05603985 −0.014 (0.003) 8.4 × 10−7 −0.013 (0.003) 3.6 × 10−5 −0.014 (0.003) 1.3 × 10−7 −0.014 (0.003) 2.4 × 10−7
cg04324276 −0.015 (0.003) 3.2 × 10−6 −0.015 (0.003) 1.2 × 10−5 −0.010 (0.003) 2.4 × 10−4 −0.010 (0.003) 5.2 × 10−4
cg25468516 −0.015 (0.003) 3.6 × 10−6 −0.014 (0.003) 3.0 × 10−5 0.011 (0.003) 2.3 × 10−4 0.012 (0.003) 1.2 × 10−4
cg22907952 −0.011 (0.002) 4.5 × 10−6 −0.010 (0.003) 6.9 × 10−5 −0.007 (0.002) 1.1 × 10−3 −0.007 (0.002) 1.5 × 10−3
cg15474579 −0.017 (0.004) 5.0 × 10−6 −0.013 (0.004) 5.2 × 10−4 −0.016 (0.003) 2.0 × 10−6 −0.016 (0.003) 7.6 × 10−6
cg20496896 0.012 (0.003) 6.7 × 10−6 0.013 (0.003) 4.6 × 10−6 0.005 (0.002) 0.06 0.005 (0.002) 0.03
cg09397246 0.018 (0.004) 1.0 × 10−5 0.018 (0.004) 3.1 × 10−5 0.017 (0.003) 5.6 × 10−7 0.017 (0.003) 1.9 × 10−6
cg26405020 0.014 (0.003) 1.2 × 10−5 0.014 (0.003) 1.4 × 10−5 0.008 (0.003) 2.6 × 10−3 0.007 (0.003) 8.2 × 10−3
cg18236066 −0.014 (0.003) 1.3 × 10−5 −0.015 (0.003) 2.5 × 10−5 −0.011 (0.003) 1.4 × 10−4 −0.011 (0.003) 1.8 × 10−4
  1. Bonferroni-corrected threshold 1.4 × 10−5
  2. Current-Never: adjusted for age, sex, BMI, Houseman estimates, batch effects
  3. Adjusted model: current-never, adjusted for age, sex, BMI, Houseman estimates, batch effects, systolic blood pressure, total cholesterol, triglycerides, daily alcohol intake, type 2 diabetes mellitus
  4. Current-Former: adjusted for age, sex, BMI, Houseman estimates, batch effects
  5. Adjusted model: current-former, adjusted for age, sex, BMI, Houseman estimates, batch effects, systolic blood pressure, total cholesterol, triglycerides, daily alcohol intake, type 2 diabetes mellitus