Figure 1
From: Epigenetic reprogramming of melanoma cells by vitamin C treatment
The relative transcription levels of TETs and SVCTs in melanoma cells. Levels of TETs and SVCTs (mean) in a healthy melanocyte line are set up as ‘1’. (A) The mRNA levels of TET1 and TET2, measured by qRT-PCR, are decreased in melanoma cell lines derived from RGP, VGP, and metastatic stages compared to a healthy melanocyte line FOM-113. (B) The mRNA levels of SVCTs are either decreased or increased in the examined melanoma cell lines. Comparatively, the transcription levels of both SVCTs are decreased in the melanoma cell lines (C8161, A2058) derived from the metastatic stage. (Mean ± SD, *P < 0.05).