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Figure 3 | Clinical Epigenetics

Figure 3

From: Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis

Figure 3

Differentially expressed miRNA in the HMEC model system. (A) Expression profile of the four differentially expressed miRNA (hsa-mir-143, hsa-mir-145 hsa-mir-519a and hsa-mir-199a), and hsa-mir-519a cluster associated miRNAs (hsa-mir-522 and hsa-mir-512) in vHMEC. hsa-mir-519a clustered RNA exhibited a similar but not significant change in expression in vHMEC, indicating that this cluster may be regulated as a unit during carcinogenesis. (B) The hsa-mir-143/145 cluster that exhibits simultaneous silencing in vHMEC. (C) The hsa-mir-519a cluster on chromosome 19q13.41 contains many other miRNA including two also assayed by the TLDA.

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