Table 3 The performance of combinations of ZNF582 ^m and HPV tests in detecting CIN3+ in ASC

All ages (N = 242)

ZNF582 ^m

82.43

76.79

78.52

15.52 (7.73 to 31.18)

<0.001

HPV-HR

99.33

38.76

57.37

-

<0.001

HPV-16/18

66.22

88.10

81.41

14.50 (7.42 to 28.37)

<0.001

ZNF582 ^m or HPV-16/18

89.19

70.24

76.03

19.47 (8.71 to 43.54)

<0.001

ZNF582 ^m or HPV-16/18/52/58

95.95

48.81

63.22

14.79 (6.39 to 34.19)

<0.001

ZNF582 ^m or HPV-HR

99.33

34.02

54.10

76.84 (4.68 to 1262.62)

0.002

ZNF582 ^m and HPV-HR

82.43

81.55

81.82

-

<0.001

ZNF582 ^m and HPV-16/18

59.46

94.64

83.88

25.91 (11.45 to 58.61)

<0.001

Age under 30 (N = 31)

Sensitivity (%)

Specificity (%)

Accuracy (%)

OR (95% CI)

P value

ZNF582 ^m

75.00

81.48

80.65

13.20 (1.12 to 154.92)

0.043

HPV-HR

90.00

41.07

48.49

-

0.233

HPV-16/18

75.00

92.59

90.33

37.50 (2.56 to 548.36)

0.009

ZNF582 ^m or HPV-16/18

75.00

77.78

77.42

10.50 (0.92 to 120.26)

0.063

ZNF582 ^m or HPV-HR

90.00

37.50

45.46

-

0.274

ZNF582 ^m and HPV-HR

75.00

85.19

83.87

17.25 (1.42 to 210.12)

0.028

ZNF582 ^m and HPV-16/18

75.00

96.30

93.55

78.00 (3.81 to 1595.87)

0.004

Postmenopausal Women

Sensitivity (%)

Specificity (%)

Accuracy (%)

OR (95% CI)

P value

ZNF582 ^m

88.89

69.77

75.41

18.46 (3.70 to 92.14)

<0.001

HPV-HR

97.37

48.86

63.49

-

0.001

HPV-16/18

88.89

86.05

86.89

49.33 (8.97 to 271.23)

<0.001

ZNF582 ^m or HPV-16/18

97.37

62.50

73.02

-

<0.001

ZNF582 ^m or HPV-HR

97.37

44.32

60.32

-

0.001

ZNF582 ^m and HPV-HR

88.89

74.42

78.69

23.27 (4.60 to 117.81)

<0.001

ZNF582 ^m and HPV-16/18

77.78

93.02

88.52

46.67 (9.27 to 234.86)

<0.001