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Table 3 The performance of combinations of ZNF582 m and HPV tests in detecting CIN3+ in ASC

From: Comparison of HPV genotyping and methylated ZNF582 as triage for women with equivocal liquid-based cytology results

Tests Sensitivity (%) Specificity (%) Accuracy (%) OR (95% CI) P value
All ages (N = 242)      
ZNF582 m 82.43 76.79 78.52 15.52 (7.73 to 31.18) <0.001
HPV-HR 99.33 38.76 57.37 - <0.001
HPV-16/18 66.22 88.10 81.41 14.50 (7.42 to 28.37) <0.001
ZNF582 m or HPV-16/18 89.19 70.24 76.03 19.47 (8.71 to 43.54) <0.001
ZNF582 m or HPV-16/18/52/58 95.95 48.81 63.22 14.79 (6.39 to 34.19) <0.001
ZNF582 m or HPV-HR 99.33 34.02 54.10 76.84 (4.68 to 1262.62) 0.002
ZNF582 m and HPV-HR 82.43 81.55 81.82 - <0.001
ZNF582 m and HPV-16/18 59.46 94.64 83.88 25.91 (11.45 to 58.61) <0.001
Age under 30 (N = 31) Sensitivity (%) Specificity (%) Accuracy (%) OR (95% CI) P value
ZNF582 m 75.00 81.48 80.65 13.20 (1.12 to 154.92) 0.043
HPV-HR 90.00 41.07 48.49 - 0.233
HPV-16/18 75.00 92.59 90.33 37.50 (2.56 to 548.36) 0.009
ZNF582 m or HPV-16/18 75.00 77.78 77.42 10.50 (0.92 to 120.26) 0.063
ZNF582 m or HPV-HR 90.00 37.50 45.46 - 0.274
ZNF582 m and HPV-HR 75.00 85.19 83.87 17.25 (1.42 to 210.12) 0.028
ZNF582 m and HPV-16/18 75.00 96.30 93.55 78.00 (3.81 to 1595.87) 0.004
Postmenopausal Women Sensitivity (%) Specificity (%) Accuracy (%) OR (95% CI) P value
ZNF582 m 88.89 69.77 75.41 18.46 (3.70 to 92.14) <0.001
HPV-HR 97.37 48.86 63.49 - 0.001
HPV-16/18 88.89 86.05 86.89 49.33 (8.97 to 271.23) <0.001
ZNF582 m or HPV-16/18 97.37 62.50 73.02 - <0.001
ZNF582 m or HPV-HR 97.37 44.32 60.32 - 0.001
ZNF582 m and HPV-HR 88.89 74.42 78.69 23.27 (4.60 to 117.81) <0.001
ZNF582 m and HPV-16/18 77.78 93.02 88.52 46.67 (9.27 to 234.86) <0.001
  1. P values determined by chi-square test or Fisher’s exact test; CI, confidence interval; HPV, human papillomavirus; HPV-HR, high-risk human papillomavirus; OR, odds ratio for CIN3 +; ZNF582 m, methylated ZNF582.