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Table 5 Hypomethylated and transcriptionally repressed genes ( n = 56) in HCC as compared to cancer-free tissue

From: DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma

Cell communication (8) a
Gene Name P value Coefficient
CRHBP 0.001 −5.0
DCN 0.027 −2.8
DLG2 0.035 −1.2
EMR1 0.009 −1.5
GPR128 0.002 −2.9
GRM8 0.004 −2.0
IGF1 0.046 −1.9
SPG20 0.006 −1.1
Immune response (9) a
Gene Name P value Coefficient
CLEC1B 0.002 −2.6
COLEC10 0.00002 −3.5
FCRL6 0.034 −1.1
FPR1 0.025 −1.8
IL1RL1 0.046 −1.6
LILRA5 0.028 −1.5
MARCO 0.0006 −3.2
NLRP12 0.003 −1.1
RAG1 0.022 −1.2
Transport (7) a
Gene Name P value Coefficient
AQP4 0.043 −1.1
EHD3 0.008 −2.4
LST-3TM12 0.021 −2.3
LYVE1 0.0002 −3.7
SLC38A4 0.038 −1.9
SLC6A19 0.018 −1.2
SYTL3 0.035 −1.2
Metabolic and cellular process (15) a
Gene Name P value Coefficient
DERA 0.016 −1.1
FBXL5 0.012 −1.1
FOLH1 0.029 −1.5
FRMD4B 0.02 −1.2
GALC 0.016 −1.3
GCNT2 0.005 −1.3
GLYATL1 0.029 −1.3
HEPACAM 0.019 −3.2
HSD11B1 0.023 −1.1
KLHL3 0.007 −1.9
NME5 0.017 −1.3
PBX1 0.012 −1.1
POU6F2 0.012 −1.2
RDH14 0.021 −1.3
TBXAS1 0.031 −1.5
Cell growth, cell cycle and apoptosis (6) a
Gene Name P value Coefficient
ABI3BP 0.01 −1.4
CNTN3 0.008 −1.6
MACF1 0.003 −1.1
PDE4DIP 0.001 −1.5
PTPN13 0.021 −1.9
TBRG1 0.018 −1.5
Miscellaneous (10) a
Gene Name P value Coefficient
C14orf105 0.013 −1.3
DOCK8 0.042 −1.4
ITLN1 0.016 −1.7
MBNL2 0.021 −1.9
NEBL 0.045 −1.1
PAMR1 0.01 −2.1
PLCXD3 0.038 −1.7
RNF217 0.009 −1.1
TMEM100 0.013 −1.5
TMEM133 0.001 −1.2
ZNF385B 0.035 −1.8
  1. aNumber of genes hypermethylated and transcriptionally repressed. Coefficient and P value refer to gene expression data.