Skip to main content

Table 4 Hypermethylated and transcriptionally induced genes ( n = 49) in HCC as compared to cancer-free tissue

From: DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma

Cell communication (7) a
Gene Name P value Coefficient
BAIAP2L2 0.005 1.9
EPS8L3 0.006 3.1
MCHR1 0.019 1.4
PMCH 0.002 1.8
RASL12 0.039 1.4
SEMA3G 0.004 1.1
TNNC1 0.033 1.2
Immune response (3) a
Gene Name P value Coefficient
MICB 0.004 1.5
SLAMF8 0.015 1.6
VWF 0.041 1.0
Transport (5) a   
Gene Name P value Coefficient
KIF4A 0.006 2.2
KPNA2 0.043 1.0
SCN4A 0.014 1.4
SLC26A6 0.00004 2.3
TRIM16L 0.041 1.6
Metabolic and cellular process (15) a
Gene Name P value Coefficient
CELF6 0.019 1.0
COX7B2 0.034 2.4
DNMT3B 0.026 1.1
HIST1H4l 0.035 1.0
HKDC1 0.012 2.5
MMP12 0.014 1.9
MMP9 0.039 1.8
NEIL3 0.012 2.0
PDE4C 0.017 1.1
PIF1 0.002 1.8
PLA2G1B 0.042 1.2
RAB3B 0.008 3.6
S100P 0.031 2.7
UBE2T 0.0001 2.8
ZP3 0.006 2.0
Cell growth, cell cycle and apoptosis (9) a
Gene Name P value Coefficient
BAX 0.031 1.1
BOLA2 0.002 1.6
BOLA2B 0.002 1.6
KIAA0101 0.024 1.9
MAGEA5 0.007 4.0
PLK4 0.011 1.3
TRAF5 0.018 1.2
TRAIP 0.016 1.9
VRK1 0.013 1.0
Miscellaneous (10) a
Gene Name P value Coefficient
AIM1L 0.003 2.0
C16orf59 0.027 1.4
CSAG1 0.032 2.7
FAM189B 0.022 1.0
HRCT1 0.001 2.2
MND1 0.001 2.5
PLVAP 0.009 1.6
TRIM31 0.00001 2.2
VCY 0.049 1.8
ZWINT 0.006 1.7
  1. aNumber of genes hypermethylated and transcriptionally repressed. Coefficient and P value refer to gene expression data.