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Table 4 Hypermethylated and transcriptionally induced genes ( n = 49) in HCC as compared to cancer-free tissue

From: DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma

Cell communication (7) a

Gene Name

P value

Coefficient

BAIAP2L2

0.005

1.9

EPS8L3

0.006

3.1

MCHR1

0.019

1.4

PMCH

0.002

1.8

RASL12

0.039

1.4

SEMA3G

0.004

1.1

TNNC1

0.033

1.2

Immune response (3) a

Gene Name

P value

Coefficient

MICB

0.004

1.5

SLAMF8

0.015

1.6

VWF

0.041

1.0

Transport (5) a

  

Gene Name

P value

Coefficient

KIF4A

0.006

2.2

KPNA2

0.043

1.0

SCN4A

0.014

1.4

SLC26A6

0.00004

2.3

TRIM16L

0.041

1.6

Metabolic and cellular process (15) a

Gene Name

P value

Coefficient

CELF6

0.019

1.0

COX7B2

0.034

2.4

DNMT3B

0.026

1.1

HIST1H4l

0.035

1.0

HKDC1

0.012

2.5

MMP12

0.014

1.9

MMP9

0.039

1.8

NEIL3

0.012

2.0

PDE4C

0.017

1.1

PIF1

0.002

1.8

PLA2G1B

0.042

1.2

RAB3B

0.008

3.6

S100P

0.031

2.7

UBE2T

0.0001

2.8

ZP3

0.006

2.0

Cell growth, cell cycle and apoptosis (9) a

Gene Name

P value

Coefficient

BAX

0.031

1.1

BOLA2

0.002

1.6

BOLA2B

0.002

1.6

KIAA0101

0.024

1.9

MAGEA5

0.007

4.0

PLK4

0.011

1.3

TRAF5

0.018

1.2

TRAIP

0.016

1.9

VRK1

0.013

1.0

Miscellaneous (10) a

Gene Name

P value

Coefficient

AIM1L

0.003

2.0

C16orf59

0.027

1.4

CSAG1

0.032

2.7

FAM189B

0.022

1.0

HRCT1

0.001

2.2

MND1

0.001

2.5

PLVAP

0.009

1.6

TRIM31

0.00001

2.2

VCY

0.049

1.8

ZWINT

0.006

1.7

  1. aNumber of genes hypermethylated and transcriptionally repressed. Coefficient and P value refer to gene expression data.