DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma

Clinical Epigenetics

Table 1 Clinical and biochemical characteristics of HCC patients

Subject	Age (years)	Alcohol (units) ^a	Smoking	Child-Pugh score	HBsAg	HCVAb	Hb (g/dL)	MCV (fL)	IgA (g/L)	GGT (U/L)	CHE (U/L)	AST (U/L)	ALT (U/L)	aFP (mg/L)
1	66	>20	yes	A6	Neg	Neg	12.1	88.0	2.22	67	4,138	25	57	5,871
2	70	6	yes	A5	Neg	Neg	12.0	69.1	0.91	32	4,606	23	37	411
3	66	16	yes	A5	Neg	Neg	15.6	89.9	4.08	48	4,624	30	33	967
4	82	11	yes	A5	Neg	Neg	11.2	88.8	1.66	43	7,353	29	28	62
5	68	5	no	A5	Neg	Neg	16.0	98.1	3.98	52	7,856	25	29	190
6	60	6	yes	A5	Neg	Neg	13.8	98.6	1.60	223	3,564	38	51	5
7	75	4	yes	A5	Neg	Neg	13.7	90.3	3.28	30	7,225	28	15	431
8	71	10	yes	A5	Neg	Neg	13.3	91.4	1.56	88	8,430	24	29	21

^a1 unit is defined as 12 g of ethanol = 125-ml wine or 330-ml beer or 40-ml spirit.
Abbreviations: HBV Ag, hepatitis B virus antigen ; HCVAb, hepatitis C virus antibody; Hb, hemoglobin; MCV, mean corpuscolar volume; IgA, immunoglobulin fraction A; GGT, gamma-glutamyl transpeptidase; CHE, cholinesterase; AST, aspartate transaminase; ALT, alanine transaminase; aFP, alphafetoprotein.
Alcohol drinking defined as ≥36 g ethanol/day for males and ≥24 g ethanol/day for females.
Reference values: Hb (g/dl) 13.5 to 16; MCV (fl) 86 to 98; IgA (g/L) 0.7 to 4.0; GGT (U/l) <50; CHE (U/l) 4,650 to 14,400; AST (U/l) 8 to 50; ALT (U/l) 8 to 45; aFP (mg/L) <7.

ISSN: 1868-7083