Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat

Table 1 Enriched KEGG pathways

KEGG pathway		Score	P value	FDR	CTEA score	CTEA P value	CTEA FDR
BMI discordant
4977	Vitamin digestion and absorption	−0.23	0.002	0.098	−0.23	0.002	0.065
4614	Renin-angiotensin system	−0.23	0.003	0.098	−0.22	0.009	0.195
eLF group
260	Glycine, serine and threonine metabolism	−0.19	<0.001	<0.001	−0.16	0.001	0.033
340	Histidine metabolism	−0.13	0.002	0.052	−0.12	0.005	0.065
4977	Vitamin digestion and absorption	−0.19	0.003	0.052	−0.15	0.020	0.130
4614	Renin-angiotensin system	−0.22	0.004	0.052	−0.24	0.001	0.033
300	Lysine biosynthesis	−0.48	0.004	0.052	−0.44	0.003	0.065
780	Biotin metabolism	−0.61	0.006	0.056	−0.64	0.009	0.084
920	Sulfur metabolism	−0.29	0.006	0.056	−0.29	0.006	0.065
591	Linoleic acid metabolism	0.36	0.001	0.065	0.49	<0.001	<0.001
830	Retinol metabolism	−0.11	0.011	0.089	−0.19	0.005	0.065

1,000 permutations were performed with no probe number cutoffs. CTEA cell-type estimate adjusted.

ISSN: 1868-7083