Figure 1From: Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat Volcano plot of differences in DNA methylation between the discordant co-twins ( n  = 13 twin pairs) in the eLF group. Each point represents a CpG site (n = 456,961) with mean within-pair differences in DNA methylation between co-twins on the x-axis and − log10 of the uncorrected P value from a paired test (moderated empirical Bayes) on the y-axis. Negative methylation differences indicate hypomethylation and positive differences hypermethylation in the heavy compared to the lean co-twins. Black dots represent significantly differentially methylated CpGs (n = 1,236, FDR <0.05, mean within-pair DNA methylation difference ≥5%); red dots represent CpGs located in genes genetically associated with obesity and obesity-associated traits (T2DM, liver fat, and MetS, n = 13, Additional file 5); green dots represent CpGs located in genes previously shown to be differentially methylated in obesity and T2DM (n = 11, Additional file 6); blue dots represent CpGs located in genes genetically and epigenetically associated to obesity and obesity-associated traits (n = 3, Additional files 5 and 6).Back to article page