Skip to main content

Table 3 Difference in methylation fraction means infertile ART and fertile control groups

From: DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility

Genomic locations a

Gene

Inclusion in [ 30 ]

Infertile ART methylation fraction (mean)

Fertile control methylation fraction (mean)

Fertile control vs infertile ART ( P ) b

chr12:121824850

CCDC62

Yes

0.131

0.162

0.030

chr12:121824853

CCDC62

No

0.135

0.165

0.036

chr11:122214681

CRTAM

Yes

0.556

0.555

0.451

chr17:30783625

FLJ10260

Yes

0.606

0.586

0.197

chr5:115326619

FLJ90650

Yes

0.141

0.087

0.003

chr5:115326640

FLJ90650

No

0.144

0.100

0.015

chr5:115326626

FLJ90650

No

0.157

0.095

0.003

chr5:115326614

FLJ90650

No

0.137

0.098

0.035

chr7:50816700

GRB10

No

0.452

0.417

0.003

chr7:50816682

GRB10

No

0.268

0.245

0.029

chr7:50816674

GRB10

No

0.292

0.269

0.016

chr7:50816802

GRB10

No

0.629

0.620

0.199

chr17:70368047

GRIN2C

Yes

0.109

0.167

<0.001

chr17:70368057

GRIN2C

No

0.079

0.108

<0.001

chr11:1975300

H19

Yes

0.472

0.456

0.039

chr5:131908379

IL5

Yes

0.712

0.710

0.402

chr1:234113562

LYST

Yes

0.626

0.650

0.025

chr7:129913072

MEST

Yes

0.378

0.374

0.415

chr7:129913081

MEST

No

0.477

0.464

0.274

chr7:129913254

MEST

Yes

0.294

0.278

0.176

chr7:129913259

MEST

No

0.321

0.302

0.178

chr15:21483466

NDN

Yes

0.212

0.179

0.040

chr15:21483463

NDN

Yes

0.275

0.235

0.046

chr5:140777470

PCDHGB7

Yes

0.425

0.390

0.109

chr5:140777464

PCDHGB7

No

0.337

0.312

0.187

chr5:140777418

PCDHGB7

Yes

0.213

0.183

0.075

chr10:48448112

PTPN20B

Yes

0.247

0.199

0.045

chr10:48448103

PTPN20B

No

0.288

0.239

0.047

chr10:48448106

PTPN20B

No

0.254

0.215

0.077

chr10:48448108

PTPN20B

No

0.296

0.259

0.121

chr10:48448115

PTPN20B

Yes

0.343

0.295

0.084

chr15:22644337

SNRPN

Yes

0.298

0.287

0.313

chr15:22644327

SNRPN

No

0.243

0.269

0.095

chr15:22620469

SNRPN

Yes

0.098

0.091

0.216

chr17:33179448

TCF2

Yes

0.537

0.545

0.259

chr17:33179450

TCF2

No

0.476

0.479

0.401

chr18:27424926

TTR

Yes

0.646

0.660

0.050

  1. a.Corresponds to genome build 36.1; bvalues in italics denote significance.