DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility

Table 1 Demographic and relevant clinical data for subjects

	Infertile ART group ( n = 66)	Donor oocyte ART group ( n = 22)	Fertile control group ( n = 49)	P -value ^a,b
Maternal age (years, mean ± SD)	35.3 ± 3.7	41.5 ± 6.0^c	34.5 ± 5.0	<0.0001
Paternal age (years, mean ± SD)	36.2 ± 5.3	42.4 ± 7.1	34.9 ± 5.7	<0.0001
IVF cycle type (fresh/frozen)	58/8	18/6	Not applicable	0.1871^d
Number of ICSI cycles	9 (13.6 %)	0 (0 %)	Not applicable	0.1047^d
Gestational age (weeks, mean ± SD)	38.8 ± 1.9	37.7 ± 2.3	39.3 ± 1.0	0.0014
Birth weight (grams, mean ± SD)	3,371 ± 625	3,079.7 ± 636	3,640 ± 459	0.0007
Males (%)	32 (48.5 %)	9 (40.1 %)	25 (51.0 %)	0.7310^d
Females (%)	34 (51.5 %)	13 (59.0 %)	24 (49.0 %)	0.7310^d

^a P-values from ANOVA unless indicated; ^bvalues in italics denote significance;^cmean age of the recipient. All donors were fertile women between the ages 21 and 33; ^d P-value from chi-square. n = number of placentae.

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