Premature aging of leukocyte DNA methylation is associated with type 2 diabetes prevalence

Clinical Epigenetics

Table 2 Association of PBL methylation with T2D status in EJP - multivariable logistic modeling

Model	Dependent variable	Number (cases, non-cases)	Main effect odds ratio	P -value	Interaction odds ratio	P -value
1	T2D + IGM (groups 1 + 2 vs. groups 3 + 4)	929 (461, 468)	0.979	0.014	NA	NA
2			0.894	0.006	1.002	0.023
3			0.909	0.021	1.001	0.045
1	T2D (group 1 vs. group 4)	562 (267, 295)	0.982	0.142	NA	NA
2			0.846	0.011	1.003	0.021
3			0.853	0.02	1.003	0.022

Model 1: Independent variables: continuous age, age², methylation. Model 2: Independent variables: continuous age, age², methylation, methylation × age interaction. Model 3: Independent variables: continuous age, age², methylation, methylation × age interaction, BMI, sex, lymphocyte to granulocyte ratio. Group 1: Normal glucose metabolism (GM); Group 2: Borderline GM; Group 3: Impaired GM; Group 4: T2D; NA: Not applicable (i.e. no interaction term was introduced).

ISSN: 1868-7083