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Table 2 Association of PBL methylation with T2D status in EJP - multivariable logistic modeling

From: Premature aging of leukocyte DNA methylation is associated with type 2 diabetes prevalence

Model Dependent variable Number (cases, non-cases) Main effect odds ratio P -value Interaction odds ratio P -value
1 T2D + IGM (groups 1 + 2 vs. groups 3 + 4) 929 (461, 468) 0.979 0.014 NA NA
2 0.894 0.006 1.002 0.023
3 0.909 0.021 1.001 0.045
1 T2D (group 1 vs. group 4) 562 (267, 295) 0.982 0.142 NA NA
2 0.846 0.011 1.003 0.021
3 0.853 0.02 1.003 0.022
  1. Model 1: Independent variables: continuous age, age2, methylation. Model 2: Independent variables: continuous age, age2, methylation, methylation × age interaction. Model 3: Independent variables: continuous age, age2, methylation, methylation × age interaction, BMI, sex, lymphocyte to granulocyte ratio. Group 1: Normal glucose metabolism (GM); Group 2: Borderline GM; Group 3: Impaired GM; Group 4: T2D; NA: Not applicable (i.e. no interaction term was introduced).