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Table 3 Multivariate Cox proportional hazards analysis a of RFS according to RARβ2 hypermethylation, stratified by histology, in never-smokers

From: RARβ2 hypermethylation is associated with poor recurrence-free survival in never-smokers with adenocarcinoma of the lung

  RARβ2 hypermethylation HR 95% CI P value
A. Adenocarcinoma No 1.00   
  (N = 128) Yes 2.19 1.28 to 3.47 0.009
B. Other cell types No 1.00   
  (N = 23) Yes 3.27 0.71 to 16.23 0.16
  1. HR, hazard ratio; CI, confidence interval.
  2. aAdjusted for age, sex, differentiation, tumor size, pathologic stage, histology, adjuvant chemotherapy, and protein clusters [(β-catenin/E-cadherin), c-MET, and (cyclin D1/EGFR)].