Oxaliplatin (mg/m 2 ) | 20/15 ( n  = 3) | 20/22.5 ( n  = 3) | 20/30 ( n  = 3) | 25/30 ( n  = 3) | 40/30 ( n  = 3) | 50/30 ( n  = 22) |
---|---|---|---|---|---|---|
Visit | C1D2 | C1D2 | C1D2 | C1D2 | C1D2 | C1D2 |
AUCall (h-ng/ml) | 704.3 (228.5) | 1,178.4 (238.0) | 1,149.0 (930.3) | 1,369.1 (556.1) | 1,543.5 (502.1) | 1,286.3 (627.0) |
AUCinf (h-ng/ml) | 1,003.5 (211.1) | 1,359.3 (167.1) | 1,411.6 (1,065.1) | 1,919.4 (923.3) | 1,867.0 (387.0) | 1,455.9 (657.6) |
C max (ng/ml) | 337.3 (141.3) | 573.5 (131.1) | 446.9 (447.8) | 582.6 (270.3) | 751.7 (275.5) | 649.4 (384.5) |
t 1/2 (h) | 38.9 (31.9) | 17.9 (7.7) | 18.6 (11.9) | 23.7 (10.2) | 23.3 (15.6) | 16.5 (7.1) |
CL (l/h/m2) | 15.5 (3.7) | 16.7 (2.0) | 29.1 (15.7) | 19.2 (11.4) | 16.6 (3.9) | 24.5 (10.2) |
V d (l/m2) | 829.2 (580.0) | 443.5 (232.2) | 794.5 (703.8) | 587.5 (240.1) | 613.8 (541.2) | 554.0 (250.7) |