Table 3 Summary of adverse events at least possibly related to the treatment reported by ≥10% of patients overall (safety population)

Non-hematological

 Fatigue

5

10

2

17 (46)

 Nausea

9

1

4

13 (35)

 Vomiting

5

4

3

12 (32)

 Constipation

4

5

9 (24)

 Hyponatremia

4

3

7 (19)

 Hypomagnesemia

7

7 (19)

 Hypokalemia

4

2

1

7 (19)

 Hypocalcemia

5

2

7 (19)

 Peripheral neuropathy

5

1

6 (16)

 Creatinine increase

4

2

6 (16)

 Alkaline phosphatase increase

2

4

6 (16)

 Dyspnea

5

5 (14)

 Elevated AST/ALT

2

2

1

5 (14)

 Hypoalbuminemia

3

1

4 (11)

 Hyperkalemia

3

1

4 (11)

 Diarrhea

4

4 (11)

Hematological

 Anemia

2

12

4

18 (49)

 Thrombocytopenia

13

2

15 (41)

 Leukopenia

6

4

10 (27)

 Lymphocytopenia

3

3

2

8 (22)

 Neutropenia

4

1

1

6 (16)