Table 3 Age-demethylated regions within 3 to 60 months after birth in blood leukocytes
Gene symbol | Gene name | Function | Locus | Number of CpGs | Illumina ID | Region length (bp) |
|---|---|---|---|---|---|---|
PRDM16 | PR domain containing 16 | TF; zinc finger transcription factor (KRAB box) | 1p36.23-p33 | 4 | cg17001566 | 249,737 |
cg12436196 | ||||||
cg01418153 | ||||||
cg03254465 | ||||||
CITED4 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | Transcriptional co-activator; CBP and p300 binding; co-activator of AP2 | 1p34.2 | 2 | cg08719289 | 42 |
cg10705800 | ||||||
ATOH8 | Atonal homolog 8 | TF, DNA binding, transcriptional regulation; nuclease | 2p11.2 | 3 | cg05318142 | 13,349 |
cg08079596 | ||||||
cg05584950 | ||||||
HDAC4 | Histone deacetylase 4 | Histone deacetylase; reductase; transcriptional repression when tethered to a promoter | 2q37.3 | 3 | cg05870586 | 362 |
cg15058210 | ||||||
cg05903736 | ||||||
CLEC3B | C-type lectin domain family 3, member B (tetranectin) | Extracellular matrix structural protein | 3p22-p21.3 | 3 | cg02396676 | 224 |
cg22505962 | ||||||
cg06117855 | ||||||
B3GALT4 | UDP-Gal: betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 | Glycosyltransferase; synthesis of type 1 carbohydrate chains. Biosynthesis of ganglioseries glycolipid. | 6p21.3 | 2 | cg17103217 | 172 |
cg06362282 | ||||||
NFE2L3 | Nuclear factor (erytroid-derived 2)-like 3 | TF; binding of antioxidant response elements in target genes. | 7p15.2 | 2 | cg14684457 | 143 |
cg10536999 | ||||||
CUX1 | Cut-like homeobox 1 | TF; DNA binding protein. Regulate gene expression, morphogenesis, differentiation and cell cycle progression | 7q22.1 | 3 | cg10692693 | 82 |
cg05910443 | ||||||
cg03310939 | ||||||
NACC2 | NACC family member 2, BEN and BTB (POZ) domain containing | Histone deacetylase | 9q34.3 | 2 | cg14147151 | 37,942 |
cg14126392 | ||||||
BLOC1S2 | Biogenesis of lysosomal organelles complex-1, subunit 2 | Dehydrogenase; formation of lysosome-related organelles | 10q24.31 | 2 | cg26610808 | 5 |
cg15298486 | ||||||
HCCA2 | YY1-associated protein 1 | TF | 11q22 | 3 | cg01469847 | 13,771 |
cg20973931 | ||||||
cg12007048 | ||||||
ADRBK1 | Adrenergic, beta, receptor kinase 1 | Phosphorylation of beta-2-adrenergic receptor | 11q13.1 | 2 | cg13924996 | 100 |
cg11436362 | ||||||
SHANK2 | SH3 and multiple ankyrin repeat domains 2 | Molecular scaffold in the postsynaptic density | 11q13.2 | 2 | cg11155924 | 68,036 |
cg27643147 | ||||||
PSTPIP1 | Proline-serine-threonine phosphatase interacting protein 1 | CD2 binding protein. CD2-triggered T cell activation; membrane trafficking regulatory protein | 15q24.3 | 2 | cg26227523 | 1,804 |
cg21322248 | ||||||
GPRC5C | G protein-coupled receptor, family C, group 5, member C | G-protein coupled receptor; cellular effects of retinoic acid (?) | 17q25 | 3 | cg12776171 | 157 |
cg26663490 | ||||||
cg16120833 | ||||||
MGAT5B | Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl glucosaminyltransferase, isoenzyme B | Synthesis of complex cell surface N-glycans | 17q25.2 | 2 | cg23838005 | 66 |
cg05514299 | ||||||
ARID3A | AT-rich interactive domain 3A (BRIGHT-like) | TF; cell lineage regulation; cell cycle control; chromatin structure modification | 19p13.3 | 4 | cg12713583 | 6,988 |
cg02001279 | ||||||
cg18598117 | ||||||
cg01774027 | ||||||
TEF | Thyrotrophic embryonic factor | TF | 22q13.2 | 2 | cg20534570 | 419 |
cg13228442 | ||||||
TSPO | Translocator protein (18 kDa) | Steroid hormone synthesis | 22q13.31 | 2 | cg00343092 | 722 |
cg08909806 |