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Table 3 Age-demethylated regions within 3 to 60 months after birth in blood leukocytes

From: Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes

Gene symbol Gene name Function Locus Number of CpGs Illumina ID Region length (bp)
PRDM16 PR domain containing 16 TF; zinc finger transcription factor (KRAB box) 1p36.23-p33 4 cg17001566 249,737
cg12436196
cg01418153
cg03254465
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Transcriptional co-activator; CBP and p300 binding; co-activator of AP2 1p34.2 2 cg08719289 42
cg10705800
ATOH8 Atonal homolog 8 TF, DNA binding, transcriptional regulation; nuclease 2p11.2 3 cg05318142 13,349
cg08079596
cg05584950
HDAC4 Histone deacetylase 4 Histone deacetylase; reductase; transcriptional repression when tethered to a promoter 2q37.3 3 cg05870586 362
cg15058210
cg05903736
CLEC3B C-type lectin domain family 3, member B (tetranectin) Extracellular matrix structural protein 3p22-p21.3 3 cg02396676 224
cg22505962
cg06117855
B3GALT4 UDP-Gal: betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 Glycosyltransferase; synthesis of type 1 carbohydrate chains. Biosynthesis of ganglioseries glycolipid. 6p21.3 2 cg17103217 172
cg06362282
NFE2L3 Nuclear factor (erytroid-derived 2)-like 3 TF; binding of antioxidant response elements in target genes. 7p15.2 2 cg14684457 143
cg10536999
CUX1 Cut-like homeobox 1 TF; DNA binding protein. Regulate gene expression, morphogenesis, differentiation and cell cycle progression 7q22.1 3 cg10692693 82
cg05910443
cg03310939
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing Histone deacetylase 9q34.3 2 cg14147151 37,942
cg14126392
BLOC1S2 Biogenesis of lysosomal organelles complex-1, subunit 2 Dehydrogenase; formation of lysosome-related organelles 10q24.31 2 cg26610808 5
cg15298486
HCCA2 YY1-associated protein 1 TF 11q22 3 cg01469847 13,771
cg20973931
cg12007048
ADRBK1 Adrenergic, beta, receptor kinase 1 Phosphorylation of beta-2-adrenergic receptor 11q13.1 2 cg13924996 100
cg11436362
SHANK2 SH3 and multiple ankyrin repeat domains 2 Molecular scaffold in the postsynaptic density 11q13.2 2 cg11155924 68,036
cg27643147
PSTPIP1 Proline-serine-threonine phosphatase interacting protein 1 CD2 binding protein. CD2-triggered T cell activation; membrane trafficking regulatory protein 15q24.3 2 cg26227523 1,804
cg21322248
GPRC5C G protein-coupled receptor, family C, group 5, member C G-protein coupled receptor; cellular effects of retinoic acid (?) 17q25 3 cg12776171 157
cg26663490
cg16120833
MGAT5B Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl glucosaminyltransferase, isoenzyme B Synthesis of complex cell surface N-glycans 17q25.2 2 cg23838005 66
cg05514299
ARID3A AT-rich interactive domain 3A (BRIGHT-like) TF; cell lineage regulation; cell cycle control; chromatin structure modification 19p13.3 4 cg12713583 6,988
cg02001279
cg18598117
cg01774027
TEF Thyrotrophic embryonic factor TF 22q13.2 2 cg20534570 419
cg13228442
TSPO Translocator protein (18 kDa) Steroid hormone synthesis 22q13.31 2 cg00343092 722
cg08909806