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Table 2 Age-methylated regions within 3 to 60 months after birth in blood leukocytes

From: Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes

Gene symbol Gene name Function Locus Number of CpGs Illumina ID Region length (bp)
TTC22 Tetratricopeptide repeat domain 22 Mediate protein-protein interactions and chaperone activity 1p32.3 3 cg24550149 454
cg15645660
cg11949335
SPEG SPEG complex locus Myocyte cytoskeletal development and marker of differentiated vascular smooth cells 2q35 3 cg14074251 51,924
cg26530345
cg02557933
SNED1 Sushi, nidogen and EGF-like domains 1 Membrane-bound signalling molecule; hormonal regulation 2q37.3 5 cg02532017 34,671
cg07644939
cg25241559
cg19075225
cg17053285
TRIM7 Tripartite motif containing 7 Ubiquitin protein ligase; Initiation of glycogen synthesis 5q35.3 2 cg17279652 170
cg26600753
DDR1 Discoidin domain receptor tyrosine kinase 1 Regulation of cell growth, differentiation and metabolism; cell communication with environment 6p21.3 3 cg16215084 238
cg00934322
cg09965419
TNXB Tenascin XB Anti-adhesive effect; matrix maturation during wound healing 6p21.3 3 cg19071976 51,088
cg16662408
cg02657865
MAD1L1 MAD1 mitotic arrest deficient-like 1 Mitotic spindle-assembly checkpoint; cell cycle control and tumour suppression 7p22 6 cg13700912 182,950
cg06555468
cg19513987
cg16026522
cg09174162
cg00963171
UPP1 Uridine phosphorylase 1 Phosphorolysis of uridine to free bases and ribose-1-phosphate 7p12.3 3 cg14983135 170
cg10317717
cg21484940
ZNF503 Zinc finger protein 503 TF; transcriptional regulation; neural precursor cell proliferation 10q22.2 2 cg13997975 553
cg03487027
DGKZ Diacylglycerol kinase, zeta Kinase; regulate diacylglycerol levels in intracellular signal transduction 11p11.2 2 cg18908017 3,940
cg09802018
B4GALNT1 Beta-1,4-N-acetyl-galactosaminyl transferase 1 Biosynthesis of G(M2) and G(D2) glycosphingolipids 12q13.3 2 cg09932758 1,936
cg25663970
BTBD11 BTB (POZ) domain containing 11 Transcription cofactor; Protein heterodimerization activity (?) 12q23.3 3 cg27567561 566
cg13935577
cg01478234
TEPP Testis, prostate and placenta expressed Unknown 16q21 2 cg12499872 91
cg00491255
CNTNAP1 Contactin-associated protein 1 Recruitment and activation of intracellular signalling pathways in neurons 17q21 2 cg16308533 39
cg11629889
TBCD Tubulin folding cofactor D Folding of beta-tubulin 17q25.3 2 cg16555866 35,310
cg00663986
NFIX Nuclear factor I/X CCAAT-binding transcription factor Transcription factor (TF) 19p13.3 4 cg06458248 9,812
cg27392771
cg01634146
cg10767662
LRFN1 Leucine-rich repeat and fibronectin type III domain containing 1 Promotes neurite outgrowth in hippocampal neurons. Regulates and maintain excitatory synapses 19q13.2 2 cg26910511 100
cg25156118
TMC2 Transmembrane channel-like 2 Ion channel; expression in the inner ear suggests that it may be crucial for normal auditory function 20p13 3 cg12233487 146
cg23648082
cg03243506
CLDN5 Claudin 5 Claudin (physical barrier to solutes); membrane protein and tight junctions 22q11.21 2 cg04463638 366
cg14553765