Skip to main content

Advertisement

Table 1 Descriptive information on the study individuals ( n= 10)

From: Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes

Child number Date of birth HLA-DR-DQ haplotype Risk class a Mode of delivery Maternal smoking during pregnancy Age at end of exclusive breast-feeding (months) Age at end of total breast-feeding (months) Samples (time points) included in the analysis after QC
1 2000.03.21 DRB1*04:01-DQB1*03:02/DRB1*04:04-DQB1*03:02 3 Caesarean section No - <3 3 m, 12 m, 24 m, 36 m, 48 m, 60 m
2 2000.04.10 DRB1*04:04-DQB1*03:02/(DR1/10)-DQB1*05:01 3 Caesarean section No 2.2 3.5 24 m, 60 m
3 2002.04.18 DRB1*04:04-DQB1*03:02/(DR1/10)-DQB1*05:01 3 Vaginal No <5 7 to 11 3 m, 6 m, 12 m, 24 m, 48 m, 60 m
4 2002.05.16 DRB1*04:04-DQB1*03:02/(DR7)-DQA1*02:01-DQB1*03:03 1 Vaginal Yes 0.2 10.5 3 m, 6 m, 12 m, 24 m, 48 m, 60 m
5 2002.08.04 DRB1*04:01-DQB1*03:02/DRB1*04:04-DQB1*03:02 3 Vaginal No 5.0 10.0 3 m, 6 m, 12 m, 24 m, 36 m, 48 m, 60 m
6 2002.08.21 DRB1*04:04-DQB1*03:02/(DR9)-DQA1:03-DQB1*03:03 3 Vaginal No <3 13 to 17 3 m, 12 m, 24 m, 48 m, 60 m
7 2002.10.04 DRB1*04:01-DQB1*03:02/ (DR8)-DQB1*04 3 Vaginal No 3.0 8.0 3 m, 6 m, 12 m, 24 m, 36 m, 48 m, 60 m
8 2002.10.29 DRB1*04:01-DQB1*03:02/(DR1/10)-DQB1*05:01 3 Caesarean section No <3 8 to 11 3 m, 6 m, 12 m, 24 m, 36 m, 48 m, 60 m
9 2002.11.20 DRB1*04:03-DQB1*03:02/(DR13)-DQB1*06:03 0 Vaginal No 5.5 9.0 3 m, 6 m, 12 m, 24 m, 36 m, 48 m, 60 m
10 2002.11.21 DRB1*04:04-DQB1*03:02/(DR1/10)-DQB1*05:01 3 Vaginal No 2.0 2.7 3 m, 6 m, 12 m, 24 m, 36 m, 48 m, 60 m
  1. aRisk for T1D classified in five classes from decreased risk (0) to strongly increased risk (4) as presented in Hekkala et al [50].
  2. HLA = human leukocyte antigen; m = months.