DNA methylation levels within 3 to 60 months after birth in genes encoding histone modifiers and chromatin remodelers. (A) Protein interactions among genes related to the chromatin remodelling machinery that contain age-modified CpG sites; protein-protein interaction (orange line); biochemical reaction (green line); factors encoded by age-demethylated genes (red) and age-methylated genes (blue). (B) Longitudinal changes in DNA methylation for two CpG sites in the genes encoding for AT-rich interactive domain-containing protein 3A (ARID3A) and the histone deacetylase 4 (HDAC4); each dot represents an individual. (C) Longitudinal changes in DNA methylation for six genes involved in the chromatin remodelling; each dot represents an individual. KDM2A = lysine (K)-specific demethylase 2A; CBX7 = chromobox homolog 7; RNF2 = E3 ubiquitin-protein ligase RING2; SP140L = SP140 nuclear body protein-like; JARID2 = jumonji, AT-rich interactive domain 2; SMARCD3 = SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 3.