Figure 4

Induced network analysis for the known protein-protein interactions between the products of genes containing age-modified CpG sites. Genes harbouring age-modified CpG sites were used as seeds to identify known protein-protein interactions (orange line), connections in a biochemical reaction (solid and dotted green lines) and genetic regulation (purple line) at high level of confidence. Node colour represents if the gene is age methylated (blue) or age demethylated (red). The solid arrow in a biochemical reaction (green) indicates protein/substrate relationship. Non-connected seed nodes are not shown.